The protection by octreotide against experimental ischemic stroke: up-regulated transcription factor Nrf2, HO-1 and down-regulated NF-κB expression.

Chen L, Wang L, Zhang X, Cui L, Xing Y, Dong L, Liu Z, Li Y, Zhang X, Wang C, Bai X, Zhang J, Zhang L, Zhao X

Brain research1 Aug 2012Cited by 69 (Europe PMC)

PMID22885292DOI10.1016/j.brainres.2012.07.052PepBankPUB-22885292

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with cerebral ischemia, octreotide reduced neurological deficit versus MCAO controls.
In plain wordsIn rats with cerebral ischemia, octreotide reduced neurological deficit versus MCAO controls.
Peptide
Octreotide
Outcome
DecreaseNeurological deficit
Study
ratn: not reported in source
permanent middle cerebral artery occlusion
Comparator
MCAO plus saline
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
50 or 100 μg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Compared with MCAO group, OCT significantly alleviated neurological deficit, lessened infarct volume and brain edema (P<0.05), upregulated the expression of Nrf2, HO-1 and SOD (P<0.05), and decreased the expression of NF-κB and MDA (P<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
OCT was administered intraperitoneally immediately after stroke.
Summary · context
Neurological deficit scores, infarct volume and brain water content were measured at 24h after stroke.
Report a problemFND-2288529201
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with cerebral ischemia, octreotide reduced infarct volume versus MCAO controls.
In plain wordsIn rats with cerebral ischemia, octreotide reduced infarct volume versus MCAO controls.
Peptide
Octreotide
Outcome
DecreaseInfarct volume
Study
ratn: not reported in source
permanent middle cerebral artery occlusion
Comparator
MCAO plus saline
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
50 or 100 μg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Compared with MCAO group, OCT significantly alleviated neurological deficit, lessened infarct volume and brain edema (P<0.05), upregulated the expression of Nrf2, HO-1 and SOD (P<0.05), and decreased the expression of NF-κB and MDA (P<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
OCT was administered intraperitoneally immediately after stroke.
Summary · context
Neurological deficit scores, infarct volume and brain water content were measured at 24h after stroke.
Report a problemFND-2288529202
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with cerebral ischemia, octreotide reduced brain edema versus MCAO controls.
In plain wordsIn rats with cerebral ischemia, octreotide reduced brain edema versus MCAO controls.
Peptide
Octreotide
Outcome
DecreaseBrain edema
Study
ratn: not reported in source
permanent middle cerebral artery occlusion
Comparator
MCAO plus saline
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
50 or 100 μg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Compared with MCAO group, OCT significantly alleviated neurological deficit, lessened infarct volume and brain edema (P<0.05), upregulated the expression of Nrf2, HO-1 and SOD (P<0.05), and decreased the expression of NF-κB and MDA (P<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
OCT was administered intraperitoneally immediately after stroke.
Summary · context
Neurological deficit scores, infarct volume and brain water content were measured at 24h after stroke.
Report a problemFND-2288529203
04AnimalAnimal study (in vivo)Mechanism
In rats with cerebral ischemia, octreotide increased Nrf2 expression versus MCAO controls.
In plain wordsIn rats with cerebral ischemia, octreotide increased Nrf2 expression versus MCAO controls.
Peptide
Octreotide
Outcome
IncreaseNrf2 expression
Study
ratn: not reported in source
permanent middle cerebral artery occlusion
Comparator
MCAO plus saline
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
50 or 100 μg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Compared with MCAO group, OCT significantly alleviated neurological deficit, lessened infarct volume and brain edema (P<0.05), upregulated the expression of Nrf2, HO-1 and SOD (P<0.05), and decreased the expression of NF-κB and MDA (P<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
OCT was administered intraperitoneally immediately after stroke.
Summary · context
Neurological deficit scores, infarct volume and brain water content were measured at 24h after stroke.
Report a problemFND-2288529204
05AnimalAnimal study (in vivo)Mechanism
In rats with cerebral ischemia, octreotide increased HO-1 expression versus MCAO controls.
In plain wordsIn rats with cerebral ischemia, octreotide increased HO-1 expression versus MCAO controls.
Peptide
Octreotide
Outcome
IncreaseHO-1 expression
Study
ratn: not reported in source
permanent middle cerebral artery occlusion
Comparator
MCAO plus saline
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
50 or 100 μg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Compared with MCAO group, OCT significantly alleviated neurological deficit, lessened infarct volume and brain edema (P<0.05), upregulated the expression of Nrf2, HO-1 and SOD (P<0.05), and decreased the expression of NF-κB and MDA (P<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
OCT was administered intraperitoneally immediately after stroke.
Summary · context
Neurological deficit scores, infarct volume and brain water content were measured at 24h after stroke.
Report a problemFND-2288529205
06AnimalAnimal study (in vivo)Mechanism
In rats with cerebral ischemia, octreotide increased SOD expression versus MCAO controls.
In plain wordsIn rats with cerebral ischemia, octreotide increased SOD expression versus MCAO controls.
Peptide
Octreotide
Outcome
IncreaseSOD expression
Study
ratn: not reported in source
permanent middle cerebral artery occlusion
Comparator
MCAO plus saline
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
50 or 100 μg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Compared with MCAO group, OCT significantly alleviated neurological deficit, lessened infarct volume and brain edema (P<0.05), upregulated the expression of Nrf2, HO-1 and SOD (P<0.05), and decreased the expression of NF-κB and MDA (P<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
OCT was administered intraperitoneally immediately after stroke.
Summary · context
Neurological deficit scores, infarct volume and brain water content were measured at 24h after stroke.
Report a problemFND-2288529206
07AnimalAnimal study (in vivo)Mechanism
In rats with cerebral ischemia, octreotide decreased NF-κB expression versus MCAO controls.
In plain wordsIn rats with cerebral ischemia, octreotide decreased NF-κB expression versus MCAO controls.
Peptide
Octreotide
Outcome
DecreaseNF-κB expression
Study
ratn: not reported in source
permanent middle cerebral artery occlusion
Comparator
MCAO plus saline
Outcome group
Inflammation markers · Nervous system and cognition
Studied dose
50 or 100 μg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Compared with MCAO group, OCT significantly alleviated neurological deficit, lessened infarct volume and brain edema (P<0.05), upregulated the expression of Nrf2, HO-1 and SOD (P<0.05), and decreased the expression of NF-κB and MDA (P<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
OCT was administered intraperitoneally immediately after stroke.
Summary · context
Neurological deficit scores, infarct volume and brain water content were measured at 24h after stroke.
Report a problemFND-2288529207
08AnimalAnimal study (in vivo)Mechanism
In rats with cerebral ischemia, octreotide decreased MDA expression versus MCAO controls.
In plain wordsIn rats with cerebral ischemia, octreotide decreased MDA expression versus MCAO controls.
Peptide
Octreotide
Outcome
DecreaseMDA expression
Study
ratn: not reported in source
permanent middle cerebral artery occlusion
Comparator
MCAO plus saline
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
50 or 100 μg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Compared with MCAO group, OCT significantly alleviated neurological deficit, lessened infarct volume and brain edema (P<0.05), upregulated the expression of Nrf2, HO-1 and SOD (P<0.05), and decreased the expression of NF-κB and MDA (P<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
OCT was administered intraperitoneally immediately after stroke.
Summary · context
Neurological deficit scores, infarct volume and brain water content were measured at 24h after stroke.
Report a problemFND-2288529208

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:36 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.