In 3D bioengineered constructs, MGF mRNA was reduced in constructs of multiple population-doubled murine myoblasts compared with parental controls.
In plain wordsIn lab-grown muscle models, the cells' own MGF messenger RNA was lower in the aged-type constructs than in control constructs.
- Peptide
- MGF / PEG-MGF
- Outcome
- DecreaseMGF mRNA in aged-phenotype constructs
- Study
mousen: not reported in source
3D bioengineered constructs of murine myoblasts- Comparator
- Parental control (CON) constructs
- Outcome group
- Aging markers · Aging and longevity
Source sentences
MPD constructs were characterized by reduced peak force development over 24 h after cell seeding, reduced transcript expression of remodelling matrix metalloproteinases, MMP2 and MMP9, with reduced differentiation/hypertrophic potential shown by reduced IGF-I, IGF-IR, IGF-IEa, MGF mRNA.
1 context sentence(design, population, supporting numbers)
The present study utilized multiple population-doubled (MPD) murine myoblasts compared with parental controls (CON), previously shown to have an aged phenotype in monolayer cultures (Sharples et al., 2011), seeded into 3D type I collagen matrices under uniaxial tension.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.