Effects of cerebrolysin administration on oxidative stress-induced apoptosis in lymphocytes from CADASIL patients.

Formichi P, Radi E, Battisti C, Di Maio G, Dotti MT, Muresanu D, Federico A

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology10 Aug 2012Cited by 5 (Europe PMC)

PMID22878905DOI10.1007/s10072-012-1174-yPepBankPUB-22878905

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In CADASIL patient lymphocytes under standard culture conditions, Cerebrolysin did not change the percentage of apoptotic cells.
In plain wordsIn lab tests, Cerebrolysin did not change cell death in CADASIL-derived lymphocytes compared with standard culture without Cerebrolysin.
Peptide
Cerebrolysin
Outcome
No significant changeApoptotic cell percentage
Study
humann = 15
Peripheral blood lymphocytes from CADASIL patients
Comparator
Standard culture without Cerebrolysin
Outcome group
Cell viability and death · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Administration of Cere to PBLs from CADASIL patients cultured under standard conditions had no effect on the percentage of apoptotic cells.
1 context sentence(design, population, supporting numbers)
Summary · context
We used peripheral blood lymphocytes (PBLs) from 15 CADASIL patients (age range 34-70 years); 2-deoxy-D-ribose (dRib), a highly reducing sugar, was used as paradigm pro-apoptotic stimulus.
Report a problemFND-2287890501
02LabIn vitro (cells)Efficacy outcome
In CADASIL patient lymphocytes, the abstract reports Cerebrolysin protection against oxidative stress-induced apoptosis in 30 % of patients.
In plain wordsIn lab tests, the abstract reports Cerebrolysin protection against stress-induced cell death in 30 % of CADASIL-derived lymphocyte samples.
Peptide
Cerebrolysin
Outcome
Not applicablePatients with protected lymphocytes
Study
humann = 15
Peripheral blood lymphocytes from CADASIL patients
Outcome group
Cell viability and death · Immune and inflammation
Studied dose
Dose not stated
Measurements
Patients with protected lymphocytes
30%
CADASIL
Source sentences
Summary
This result showed a protective effect of Cere against oxidative stress-induced apoptosis only in 30 % of the CADASIL patients, suggesting that the Notch3 gene probably does not influence the anti-apoptotic properties of Cere in vitro.
1 context sentence(design, population, supporting numbers)
Summary · context
We used peripheral blood lymphocytes (PBLs) from 15 CADASIL patients (age range 34-70 years); 2-deoxy-D-ribose (dRib), a highly reducing sugar, was used as paradigm pro-apoptotic stimulus.
Report a problemFND-2287890504
03LabIn vitro (cells)Efficacy outcome
In lymphocytes from the other 10 CADASIL patients cultured with dRib, Cerebrolysin was not associated with a significant apoptosis difference.
In plain wordsIn lab tests, cell death in ten CADASIL-derived lymphocyte samples did not differ significantly with Cerebrolysin compared with dRib culture without Cerebrolysin.
Peptide
Cerebrolysin
Outcome
No significant changeApoptotic cell percentage
Study
humann = 10
Peripheral blood lymphocytes from CADASIL patients
Comparator
dRib culture without Cerebrolysin
Outcome group
Cell viability and death · Immune and inflammation
Studied dose
Dose not stated · 48 h of cultureAs given in this study (human).
Source sentences
Summary
Administration of Cere to PBLs cultured with dRib caused a significant decrease in apoptosis after 48 h of culture in only 5 patients, whereas in the other 10 patients, Cere treatment was not associated with any significant difference in the percentage of apoptosis.
1 context sentence(design, population, supporting numbers)
Summary · context
We used peripheral blood lymphocytes (PBLs) from 15 CADASIL patients (age range 34-70 years); 2-deoxy-D-ribose (dRib), a highly reducing sugar, was used as paradigm pro-apoptotic stimulus.
Report a problemFND-2287890503
04LabIn vitro (cells)Efficacy outcome
In lymphocytes from 5 CADASIL patients cultured with dRib, Cerebrolysin significantly decreased apoptosis after 48 h.
In plain wordsIn lab tests, Cerebrolysin reduced cell death in five CADASIL-derived lymphocyte samples after 48 h compared with dRib culture without Cerebrolysin.
Peptide
Cerebrolysin
Outcome
DecreaseApoptotic cell percentage
Study
humann = 5
Peripheral blood lymphocytes from CADASIL patients
Comparator
dRib culture without Cerebrolysin
Outcome group
Cell viability and death · Immune and inflammation
Studied dose
Dose not stated · 48 h of cultureAs given in this study (human).
Source sentences
Summary
Administration of Cere to PBLs cultured with dRib caused a significant decrease in apoptosis after 48 h of culture in only 5 patients, whereas in the other 10 patients, Cere treatment was not associated with any significant difference in the percentage of apoptosis.
1 context sentence(design, population, supporting numbers)
Summary · context
We used peripheral blood lymphocytes (PBLs) from 15 CADASIL patients (age range 34-70 years); 2-deoxy-D-ribose (dRib), a highly reducing sugar, was used as paradigm pro-apoptotic stimulus.
Report a problemFND-2287890502

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

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