Mechano growth factor (MGF) promotes proliferation and inhibits differentiation of porcine satellite cells (PSCs) by down-regulation of key myogenic transcriptional factors.

Qin LL, Li XK, Xu J, Mo DL, Tong X, Pan ZC, Li JQ, Chen YS, Zhang Z, Wang C, Long QM

Molecular and cellular biochemistry9 Aug 2012Cited by 16 (Europe PMC)

PMID22875667DOI10.1007/s11010-012-1413-9PepBankPUB-22875667

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In porcine satellite cells, MGF potently stimulated proliferation.
In plain wordsIn cells, MGF made pig muscle stem cells multiply more.
Peptide
MGF / PEG-MGF
Outcome
IncreasePorcine satellite cell proliferation
Study
pign: not reported in source
Porcine satellite cells
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
MGF potently stimulated proliferation while inhibited differentiation of porcine satellite cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the effects of mechano growth factor (MGF), a spliced variant of the IGF-1 gene, on porcine satellite cells.
Report a problemFND-2287566701
02LabIn vitro (cells)Activity measurement
In porcine satellite cells, MGF inhibited differentiation.
In plain wordsIn cells, MGF slowed the maturing of pig muscle stem cells.
Peptide
MGF / PEG-MGF
Outcome
DecreasePorcine satellite cell differentiation
Study
pign: not reported in source
Porcine satellite cells
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
We show that MGF potently stimulated proliferation while inhibited differentiation of porcine satellite cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the effects of mechano growth factor (MGF), a spliced variant of the IGF-1 gene, on porcine satellite cells.
Report a problemFND-2287566702
03LabIn vitro (cells)Activity measurement
In porcine satellite cells, MGF treatment acutely down-regulated the expression of myogenic determination factor (MyoD).
In plain wordsIn cells, MGF lowered the muscle gene switch MyoD in pig muscle stem cells.
Peptide
MGF / PEG-MGF
Outcome
DecreaseMyoD expression
Study
pign: not reported in source
Porcine satellite cells
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
MGF-treatment acutely down-regulates the expression of myogenic determination factor (MyoD) and the cyclin-dependent kinase inhibitor p21.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the effects of mechano growth factor (MGF), a spliced variant of the IGF-1 gene, on porcine satellite cells.
Report a problemFND-2287566703
04LabIn vitro (cells)Activity measurement
In porcine satellite cells, MGF treatment acutely down-regulated the expression of the cyclin-dependent kinase inhibitor p21.
In plain wordsIn cells, MGF lowered the cell cycle brake p21 in pig muscle stem cells.
Peptide
MGF / PEG-MGF
Outcome
Decreasep21 expression
Study
pign: not reported in source
Porcine satellite cells
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
MGF-treatment acutely down-regulates the expression of myogenic determination factor (MyoD) and the cyclin-dependent kinase inhibitor p21.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the effects of mechano growth factor (MGF), a spliced variant of the IGF-1 gene, on porcine satellite cells.
Report a problemFND-2287566704
05LabIn vitro (cells)Activity measurement
In porcine satellite cells, MGF treatment markedly reduced the overall expression of cyclin B1.
In plain wordsIn cells, MGF lowered the cell cycle protein cyclin B1 in pig muscle stem cells.
Peptide
MGF / PEG-MGF
Outcome
DecreaseCyclin B1 expression
Study
pign: not reported in source
Porcine satellite cells
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
MGF-treatment also markedly reduced the overall expression of cyclin B1 and key factors of the myogenic regulatory and myocyte enhancer families, including Myogenein and MEF2A.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the effects of mechano growth factor (MGF), a spliced variant of the IGF-1 gene, on porcine satellite cells.
Report a problemFND-2287566705
06LabIn vitro (cells)Activity measurement
In porcine satellite cells, MGF treatment markedly reduced the expression of myogenic regulatory factor Myogenin.
In plain wordsIn cells, MGF lowered the muscle gene switch Myogenin in pig muscle stem cells.
Peptide
MGF / PEG-MGF
Outcome
DecreaseMyogenin expression
Study
pign: not reported in source
Porcine satellite cells
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
MGF-treatment also markedly reduced the overall expression of cyclin B1 and key factors of the myogenic regulatory and myocyte enhancer families, including Myogenein and MEF2A.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the effects of mechano growth factor (MGF), a spliced variant of the IGF-1 gene, on porcine satellite cells.
Report a problemFND-2287566706
07LabIn vitro (cells)Activity measurement
In porcine satellite cells, MGF treatment markedly reduced the expression of the myocyte enhancer factor MEF2A.
In plain wordsIn cells, MGF lowered the muscle gene switch MEF2A in pig muscle stem cells.
Peptide
MGF / PEG-MGF
Outcome
DecreaseMEF2A expression
Study
pign: not reported in source
Porcine satellite cells
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
MGF-treatment also markedly reduced the overall expression of cyclin B1 and key factors of the myogenic regulatory and myocyte enhancer families, including Myogenein and MEF2A.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the effects of mechano growth factor (MGF), a spliced variant of the IGF-1 gene, on porcine satellite cells.
Report a problemFND-2287566707

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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