Skip to content

Study · In vitro (cells) · 2012

8 results

Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists.

Land SC

International journal of physiology, pathophysiology and pharmacology23 Jun 2012Cited by 12 (Europe PMC)

PMID22837805 (opens in a new tab)PMCIDPMC3403564 (opens in a new tab)PepBankPUB-22837805
Source linkPubMedAsk about this study
Jump to 8 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human bronchial epithelial cells, KPV caused dose-dependent inhibition of NFκB signaling.

    In plain wordsIn human airway cells, KPV lowered an inflammation signal (NFκB) as the dose rose.

    Peptide
    KPV
    Outcome
    DecreaseNFκB signaling
    Study

    humann: not reported in source

    16HBE14o- immortalised human bronchial epithelial cells
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KPV and γMSH evoked a dose-dependent inhibition of NFκB, matrix metalloproteinase-9 activity, IL8 and eotaxin secretion.
    1 context sentence
    Summary · context
    TNFα and rhino syncitial virus (RSV)-evoked nuclear factor-κB (NFκB) signaling was measured in immortalised human bronchial epithelial cells (16HBE14o-) in response to KPV and γMSH.
  2. 02LabIn vitro (cells)Activity measurement

    In human bronchial epithelial cells, KPV caused dose-dependent inhibition of matrix metalloproteinase-9 activity.

    In plain wordsIn human airway cells, KPV lowered the activity of the enzyme MMP-9 as the dose rose.

    Peptide
    KPV
    Outcome
    DecreaseMatrix metalloproteinase-9 activity
    Study

    humann: not reported in source

    16HBE14o- immortalised human bronchial epithelial cells
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KPV and γMSH evoked a dose-dependent inhibition of NFκB, matrix metalloproteinase-9 activity, IL8 and eotaxin secretion.
    1 context sentence
    Summary · context
    TNFα and rhino syncitial virus (RSV)-evoked nuclear factor-κB (NFκB) signaling was measured in immortalised human bronchial epithelial cells (16HBE14o-) in response to KPV and γMSH.
  3. 03LabIn vitro (cells)Activity measurement

    In human bronchial epithelial cells, KPV caused dose-dependent inhibition of IL8 secretion.

    In plain wordsIn human airway cells, KPV lowered release of the inflammatory signal IL8 as the dose rose.

    Peptide
    KPV
    Outcome
    DecreaseIL8 secretion
    Study

    humann: not reported in source

    16HBE14o- immortalised human bronchial epithelial cells
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KPV and γMSH evoked a dose-dependent inhibition of NFκB, matrix metalloproteinase-9 activity, IL8 and eotaxin secretion.
    1 context sentence
    Summary · context
    TNFα and rhino syncitial virus (RSV)-evoked nuclear factor-κB (NFκB) signaling was measured in immortalised human bronchial epithelial cells (16HBE14o-) in response to KPV and γMSH.
  4. 04LabIn vitro (cells)Activity measurement

    In human bronchial epithelial cells, KPV caused dose-dependent inhibition of eotaxin secretion.

    In plain wordsIn human airway cells, KPV lowered release of the inflammatory signal eotaxin as the dose rose.

    Peptide
    KPV
    Outcome
    DecreaseEotaxin secretion
    Study

    humann: not reported in source

    16HBE14o- immortalised human bronchial epithelial cells
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KPV and γMSH evoked a dose-dependent inhibition of NFκB, matrix metalloproteinase-9 activity, IL8 and eotaxin secretion.
    1 context sentence
    Summary · context
    TNFα and rhino syncitial virus (RSV)-evoked nuclear factor-κB (NFκB) signaling was measured in immortalised human bronchial epithelial cells (16HBE14o-) in response to KPV and γMSH.
  5. 05LabIn vitro (cells)Mechanism

    In human bronchial epithelial cells, the KPV effect was associated with the nuclear import of KPV.

    In plain wordsIn human airway cells, KPV effects were linked to KPV entering the cell nucleus.

    Peptide
    KPV
    Outcome
    Not applicableKPV nuclear import
    Study

    humann: not reported in source

    16HBE14o- immortalised human bronchial epithelial cells
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The KPV effect was associated with its nuclear import, IκBα stabilisation and suppressed nuclear translocation of YFP-tagged p65RelA.
    1 context sentence
    Summary · context
    TNFα and rhino syncitial virus (RSV)-evoked nuclear factor-κB (NFκB) signaling was measured in immortalised human bronchial epithelial cells (16HBE14o-) in response to KPV and γMSH.
  6. 06LabIn vitro (cells)Mechanism

    In human bronchial epithelial cells, the KPV effect was associated with IκBα stabilisation.

    In plain wordsIn human airway cells, KPV effects were linked to a more stable IκBα protein, which holds back inflammation signals.

    Peptide
    KPV
    Outcome
    IncreaseIκBα stabilisation
    Study

    humann: not reported in source

    16HBE14o- immortalised human bronchial epithelial cells
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The KPV effect was associated with its nuclear import, IκBα stabilisation and suppressed nuclear translocation of YFP-tagged p65RelA.
    1 context sentence
    Summary · context
    TNFα and rhino syncitial virus (RSV)-evoked nuclear factor-κB (NFκB) signaling was measured in immortalised human bronchial epithelial cells (16HBE14o-) in response to KPV and γMSH.
  7. 07LabIn vitro (cells)Mechanism

    In human bronchial epithelial cells, the KPV effect was associated with suppressed nuclear translocation of YFP-tagged p65RelA.

    In plain wordsIn human airway cells, KPV effects were linked to less movement of the p65RelA protein into the nucleus.

    Peptide
    KPV
    Outcome
    DecreaseNuclear translocation of YFP-tagged p65RelA
    Study

    humann: not reported in source

    16HBE14o- immortalised human bronchial epithelial cells
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The KPV effect was associated with its nuclear import, IκBα stabilisation and suppressed nuclear translocation of YFP-tagged p65RelA.
    1 context sentence
    Summary · context
    TNFα and rhino syncitial virus (RSV)-evoked nuclear factor-κB (NFκB) signaling was measured in immortalised human bronchial epithelial cells (16HBE14o-) in response to KPV and γMSH.
  8. 08LabIn vitro (cells)Mechanism

    Competition assays revealed an interaction between KPV and the Imp-α3 binding site on p65RelA, which may involve blockade of importin-α armadillo domains 7 and 8.

    In plain wordsIn cells, tests suggest KPV interacts with the part of p65RelA that the importin uses to carry it into the nucleus.

    Peptide
    KPV
    Outcome
    Not applicableInteraction with the Imp-α3 binding site on p65RelA
    Study

    humann: not reported in source

    16HBE14o- immortalised human bronchial epithelial cells
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Competition assays revealed an interaction between KPV and the Imp-α3 binding site on p65RelA which may involve blockade of the importin-α armadillo domain 7 and 8.
    1 context sentence
    Summary · context
    TNFα and rhino syncitial virus (RSV)-evoked nuclear factor-κB (NFκB) signaling was measured in immortalised human bronchial epithelial cells (16HBE14o-) in response to KPV and γMSH.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.