Combined administration of cerebrolysin and donepezil induces plastic changes in prefrontal cortex in aged mice.

Alcántara-González F, Mendoza-Perez CR, Zaragoza N, Juarez I, Arroyo-García LE, Gamboa C, De La Cruz F, Zamudio S, Garcia-Dolores F, Flores G

Synapse (New York, N.Y.)13 Aug 2012Cited by 42 (Europe PMC)

PMID22826038DOI10.1002/syn.21588PepBankPUB-22826038

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In aged mice, Cbl increased locomotor activity without a synergistic effect with Dnp.
In plain wordsIn mice, Cbl increased locomotor activity without a synergistic effect with Dnp.
Peptide
Cerebrolysin
Outcome
IncreaseLocomotor activity with Cbl
Study
mousen: not reported in source
9-months-old mice
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
Dose not stated · 2 monthsAs given in this study (mouse).
Source sentences
Summary
Results showed that Cbl and Dnp induced an increase in locomotor activity without synergistic effect.
1 context sentence(design, population, supporting numbers)
Summary · context
Cbl and Dnp were administrated daily for 2 months to 9-months-old mice.
Report a problemFND-2282603801
02AnimalAnimal study (in vivo)Mechanism
In aged mice, Cbl treatment modified dendritic morphology in PFC, DH, DG and the NAcc shell.
In plain wordsIn mice, Cbl treatment changed dendritic morphology across several limbic brain regions.
Peptide
Cerebrolysin
Outcome
Direction not reportedDendritic morphology across limbic regions
Study
mousen: not reported in source
9-months-old mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 2 monthsAs given in this study (mouse).
Source sentences
Summary
The Cbl or Dnp treatment modified the dendritic morphology of neurons from prefrontal cortex (PFC), dorsal hippocampus (DH), dentate gyrus (DG), and the shell of nucleus accumbens (NAcc).
1 context sentence(design, population, supporting numbers)
Summary · context
Cbl and Dnp were administrated daily for 2 months to 9-months-old mice.
Report a problemFND-2282603803
03AnimalAnimal study (in vivo)Mechanism
In aged mice, Cbl treatment increased total dendritic length in the studied limbic regions.
In plain wordsIn mice, Cbl treatment increased total dendritic length in the studied brain regions.
Peptide
Cerebrolysin
Outcome
IncreaseTotal dendritic length with Cbl
Study
mousen: not reported in source
9-months-old mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 2 monthsAs given in this study (mouse).
Source sentences
Summary
These changes show an increase in the total dendritic length and spine density, resulting in an improvement of dendritic arborization.
2 context sentences(design, population, supporting numbers)
Summary · context
The Cbl or Dnp treatment modified the dendritic morphology of neurons from prefrontal cortex (PFC), dorsal hippocampus (DH), dentate gyrus (DG), and the shell of nucleus accumbens (NAcc).
Summary · context
Cbl and Dnp were administrated daily for 2 months to 9-months-old mice.
Report a problemFND-2282603804
04AnimalAnimal study (in vivo)Mechanism
In aged mice, Cbl treatment increased spine density in the studied limbic regions.
In plain wordsIn mice, Cbl treatment increased dendritic spine density in the studied brain regions.
Peptide
Cerebrolysin
Outcome
IncreaseSpine density with Cbl
Study
mousen: not reported in source
9-months-old mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 2 monthsAs given in this study (mouse).
Source sentences
Summary
These changes show an increase in the total dendritic length and spine density, resulting in an improvement of dendritic arborization.
2 context sentences(design, population, supporting numbers)
Summary · context
The Cbl or Dnp treatment modified the dendritic morphology of neurons from prefrontal cortex (PFC), dorsal hippocampus (DH), dentate gyrus (DG), and the shell of nucleus accumbens (NAcc).
Summary · context
Cbl and Dnp were administrated daily for 2 months to 9-months-old mice.
Report a problemFND-2282603805
05AnimalAnimal study (in vivo)Mechanism
In aged mice, Cbl treatment improved dendritic arborization in the studied limbic regions.
In plain wordsIn mice, Cbl treatment improved dendritic branching in the studied brain regions.
Peptide
Cerebrolysin
Outcome
IncreaseDendritic arborization with Cbl
Study
mousen: not reported in source
9-months-old mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 2 monthsAs given in this study (mouse).
Source sentences
Summary
These changes show an increase in the total dendritic length and spine density, resulting in an improvement of dendritic arborization.
2 context sentences(design, population, supporting numbers)
Summary · context
The Cbl or Dnp treatment modified the dendritic morphology of neurons from prefrontal cortex (PFC), dorsal hippocampus (DH), dentate gyrus (DG), and the shell of nucleus accumbens (NAcc).
Summary · context
Cbl and Dnp were administrated daily for 2 months to 9-months-old mice.
Report a problemFND-2282603806

Studies that did not test the peptide alone3

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

06AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In aged mice, Cbl and Dnp increased locomotor activity without a synergistic effect.
In plain wordsIn mice, Cbl and Dnp increased locomotor activity without a synergistic effect.
Peptide
Cerebrolysin
Outcome
IncreaseLocomotor activity with Cbl and Dnp
Study
mousen: not reported in source
9-months-old mice
Outcome group
Exercise and physical function · Nervous system and cognition
Source sentences
Summary
Results showed that Cbl and Dnp induced an increase in locomotor activity without synergistic effect.
1 context sentence(design, population, supporting numbers)
Summary · context
Cbl and Dnp were administrated daily for 2 months to 9-months-old mice.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-2282603802
07AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In aged mice, combined Cbl and Dnp showed a synergistic effect on branching order of PFC pyramidal neurons.
In plain wordsIn mice, combined Cbl and Dnp showed a synergistic effect on prefrontal neuron branching order.
Peptide
Cerebrolysin
Outcome
IncreasePFC pyramidal neuron branching order with Cbl and Dnp
Study
mousen: not reported in source
9-months-old mice
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Prominently, a synergistic effect of Cbl and Dnp was observed on branching order and total dendritic length of pyramidal neurons from PFC.
1 context sentence(design, population, supporting numbers)
Summary · context
Cbl and Dnp were administrated daily for 2 months to 9-months-old mice.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-2282603807
08AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In aged mice, combined Cbl and Dnp showed a synergistic effect on total dendritic length of PFC pyramidal neurons.
In plain wordsIn mice, combined Cbl and Dnp showed a synergistic effect on total dendritic length in prefrontal neurons.
Peptide
Cerebrolysin
Outcome
IncreasePFC pyramidal neuron total dendritic length with Cbl and Dnp
Study
mousen: not reported in source
9-months-old mice
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Prominently, a synergistic effect of Cbl and Dnp was observed on branching order and total dendritic length of pyramidal neurons from PFC.
1 context sentence(design, population, supporting numbers)
Summary · context
Cbl and Dnp were administrated daily for 2 months to 9-months-old mice.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-2282603808

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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Terms as the source lists them.

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