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Study · In vitro (cells) · rat · 2012

5 results

Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture.

Khavinson VKh, Linkova NS, Kvetnoy IM, Kvetnaia TV, Polyakova VO, Korf HW

Bulletin of experimental biology and medicine1 Jun 2012Cited by 12 (Europe PMC)

PMID22816096 (opens in a new tab)DOI10.1007/s10517-012-1689-5 (opens in a new tab)PepBankPUB-22816096
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In rat pinealocyte culture, epithalone stimulated synthesis of the enzyme AANAT.

    In plain wordsIn rat pineal cells in the lab, epithalone raised production of the melatonin-making enzyme AANAT.

    Peptide
    Epitalon
    Outcome
    IncreaseAANAT synthesis
    Study

    ratn: not reported in source

    Rat pinealocyte culture
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Epithalone stimulated AANAT and pCREB synthesis
    1 context sentence
    Summary · context
    The effects of epithalone and vilone peptides on the synthesis of melatonin and factors involved in this process, arylalkylamine-N-acetyltransferase (AANAT) enzyme and pCREB transcription protein, were studied in rat pinealocyte culture.
  2. 02LabIn vitro (cells)Mechanism

    In rat pinealocyte culture, epithalone stimulated synthesis of the transcription protein pCREB.

    In plain wordsIn rat pineal cells in the lab, epithalone raised production of the protein pCREB.

    Peptide
    Epitalon
    Outcome
    IncreasepCREB synthesis
    Study

    ratn: not reported in source

    Rat pinealocyte culture
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Epithalone stimulated AANAT and pCREB synthesis
    1 context sentence
    Summary · context
    The effects of epithalone and vilone peptides on the synthesis of melatonin and factors involved in this process, arylalkylamine-N-acetyltransferase (AANAT) enzyme and pCREB transcription protein, were studied in rat pinealocyte culture.
  3. 03LabIn vitro (cells)Mechanism

    In rat pinealocyte culture, epithalone increased the melatonin level in the culture medium.

    In plain wordsIn rat pineal cells in the lab, epithalone raised the melatonin level in the culture medium.

    Peptide
    Epitalon
    Outcome
    IncreaseMelatonin level in culture medium
    Study

    ratn: not reported in source

    Rat pinealocyte culture
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Epithalone stimulated AANAT and pCREB synthesis and increased melatonin level in culture medium.
    1 context sentence
    Summary · context
    The effects of epithalone and vilone peptides on the synthesis of melatonin and factors involved in this process, arylalkylamine-N-acetyltransferase (AANAT) enzyme and pCREB transcription protein, were studied in rat pinealocyte culture.

Studies that did not test the peptide alone2

In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Epitalon.

  1. 04LabNot a test of Epitalon aloneIn vitro (cells)Mechanism

    In rat pinealocyte culture, adding norepinephrine and peptides together potentiated the expression of AANAT.

    In plain wordsIn rat pineal cells in the lab, peptides with norepinephrine raised AANAT expression more than without the peptides.

    Peptide
    Epitalon
    Outcome
    IncreaseAANAT expression with norepinephrine
    Study

    ratn: not reported in source

    Rat pinealocyte culture
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Simultaneous addition of norepinephrine and peptides into the culture potentiated the expression of AANAT and pCREB.
    1 context sentence
    Summary · context
    The effects of epithalone and vilone peptides on the synthesis of melatonin and factors involved in this process, arylalkylamine-N-acetyltransferase (AANAT) enzyme and pCREB transcription protein, were studied in rat pinealocyte culture.

    In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.

  2. 05LabNot a test of Epitalon aloneIn vitro (cells)Mechanism

    In rat pinealocyte culture, adding norepinephrine and peptides together potentiated the expression of pCREB.

    In plain wordsIn rat pineal cells in the lab, peptides with norepinephrine raised pCREB expression more than without the peptides.

    Peptide
    Epitalon
    Outcome
    IncreasepCREB expression with norepinephrine
    Study

    ratn: not reported in source

    Rat pinealocyte culture
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Simultaneous addition of norepinephrine and peptides into the culture potentiated the expression of AANAT and pCREB.
    1 context sentence
    Summary · context
    The effects of epithalone and vilone peptides on the synthesis of melatonin and factors involved in this process, arylalkylamine-N-acetyltransferase (AANAT) enzyme and pCREB transcription protein, were studied in rat pinealocyte culture.

    In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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