Peptides tissue-specifically stimulate cell differentiation during their aging.

Khavinson VKh, Linkova NS, Polyakova VO, Kheifets OV, Tarnovskaya SI, Kvetnoy IM

Bulletin of experimental biology and medicine1 May 2012Cited by 6 (Europe PMC)

PMID22808515DOI10.1007/s10517-012-1664-1PepBankPUB-22808515

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In human pancreatic cell cultures, pancragen stimulated CXCL12 expression.
In plain wordsIn cells from human pancreas, pancragen increased CXCL12 expression.
Peptide
Pancragen (KEDW)
Outcome
IncreaseCXCL12 expression
Study
humann: not reported in source
Human embryonic pancreatic cells
Outcome group
Receptor activity and mechanism · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
The expression of differentiation factors CXCL12, Hoxa3, and WEGC1 was tissue-specifically stimulated by short peptides: pancragen (Lys-Glu-Asp-Trp) in pancreatic cells, bronchogen (Ala-Glu-Asp-Leu) in bronchial epithelial cells, and vesugen (Lys-Glu-Asp) in fibroblasts.
1 context sentence(design, population, supporting numbers)
Summary · context
We verified expression of CXCL12 and Hoxa3 transcription factors of differentiation in cultures of human embryonic pancreatic and bronchial cells and CXCL12 and WEGC1 factors in a culture of human prostatic fibroblasts.
Report a problemFND-2280851501
02LabIn vitro (cells)Mechanism
In human pancreatic cell cultures, pancragen stimulated Hoxa3 expression.
In plain wordsIn cells from human pancreas, pancragen increased Hoxa3 expression.
Peptide
Pancragen (KEDW)
Outcome
IncreaseHoxa3 expression
Study
humann: not reported in source
Human embryonic pancreatic cells
Outcome group
Receptor activity and mechanism · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
The expression of differentiation factors CXCL12, Hoxa3, and WEGC1 was tissue-specifically stimulated by short peptides: pancragen (Lys-Glu-Asp-Trp) in pancreatic cells, bronchogen (Ala-Glu-Asp-Leu) in bronchial epithelial cells, and vesugen (Lys-Glu-Asp) in fibroblasts.
1 context sentence(design, population, supporting numbers)
Summary · context
We verified expression of CXCL12 and Hoxa3 transcription factors of differentiation in cultures of human embryonic pancreatic and bronchial cells and CXCL12 and WEGC1 factors in a culture of human prostatic fibroblasts.
Report a problemFND-2280851502
03LabIn vitro (cells)Mechanism
In human bronchial epithelial cultures, bronchogen stimulated CXCL12 expression.
In plain wordsIn human airway cells, bronchogen increased CXCL12 expression.
Peptide
Bronchogen (AEDL)
Outcome
IncreaseCXCL12 expression
Study
humann: not reported in source
Human bronchial epithelial cells
Outcome group
Receptor activity and mechanism · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
The expression of differentiation factors CXCL12, Hoxa3, and WEGC1 was tissue-specifically stimulated by short peptides: pancragen (Lys-Glu-Asp-Trp) in pancreatic cells, bronchogen (Ala-Glu-Asp-Leu) in bronchial epithelial cells, and vesugen (Lys-Glu-Asp) in fibroblasts.
1 context sentence(design, population, supporting numbers)
Summary · context
We verified expression of CXCL12 and Hoxa3 transcription factors of differentiation in cultures of human embryonic pancreatic and bronchial cells and CXCL12 and WEGC1 factors in a culture of human prostatic fibroblasts.
Report a problemFND-2280851503
04LabIn vitro (cells)Mechanism
In human bronchial epithelial cultures, bronchogen stimulated Hoxa3 expression.
In plain wordsIn human airway cells, bronchogen increased Hoxa3 expression.
Peptide
Bronchogen (AEDL)
Outcome
IncreaseHoxa3 expression
Study
humann: not reported in source
Human bronchial epithelial cells
Outcome group
Receptor activity and mechanism · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
The expression of differentiation factors CXCL12, Hoxa3, and WEGC1 was tissue-specifically stimulated by short peptides: pancragen (Lys-Glu-Asp-Trp) in pancreatic cells, bronchogen (Ala-Glu-Asp-Leu) in bronchial epithelial cells, and vesugen (Lys-Glu-Asp) in fibroblasts.
1 context sentence(design, population, supporting numbers)
Summary · context
We verified expression of CXCL12 and Hoxa3 transcription factors of differentiation in cultures of human embryonic pancreatic and bronchial cells and CXCL12 and WEGC1 factors in a culture of human prostatic fibroblasts.
Report a problemFND-2280851504
05LabIn vitro (cells)Mechanism
In human prostatic fibroblast cultures, vesugen stimulated CXCL12 expression.
In plain wordsIn human prostate cells, vesugen increased CXCL12 expression.
Peptide
Vesugen (KED)
Outcome
IncreaseCXCL12 expression
Study
humann: not reported in source
Human prostatic fibroblasts
Outcome group
Receptor activity and mechanism · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
The expression of differentiation factors CXCL12, Hoxa3, and WEGC1 was tissue-specifically stimulated by short peptides: pancragen (Lys-Glu-Asp-Trp) in pancreatic cells, bronchogen (Ala-Glu-Asp-Leu) in bronchial epithelial cells, and vesugen (Lys-Glu-Asp) in fibroblasts.
1 context sentence(design, population, supporting numbers)
Summary · context
We verified expression of CXCL12 and Hoxa3 transcription factors of differentiation in cultures of human embryonic pancreatic and bronchial cells and CXCL12 and WEGC1 factors in a culture of human prostatic fibroblasts.
Report a problemFND-2280851505
06LabIn vitro (cells)Mechanism
In human prostatic fibroblast cultures, vesugen stimulated WEGC1 expression.
In plain wordsIn human prostate cells, vesugen increased WEGC1 expression.
Peptide
Vesugen (KED)
Outcome
IncreaseWEGC1 expression
Study
humann: not reported in source
Human prostatic fibroblasts
Outcome group
Receptor activity and mechanism · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
The expression of differentiation factors CXCL12, Hoxa3, and WEGC1 was tissue-specifically stimulated by short peptides: pancragen (Lys-Glu-Asp-Trp) in pancreatic cells, bronchogen (Ala-Glu-Asp-Leu) in bronchial epithelial cells, and vesugen (Lys-Glu-Asp) in fibroblasts.
1 context sentence(design, population, supporting numbers)
Summary · context
We verified expression of CXCL12 and Hoxa3 transcription factors of differentiation in cultures of human embryonic pancreatic and bronchial cells and CXCL12 and WEGC1 factors in a culture of human prostatic fibroblasts.
Report a problemFND-2280851506

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 4Current
21 Oct 2026, 17:05 UTC
Study results updated
Versions 2 to 3
21 Oct 2026, 16:35 UTC
The same notice was added 2 times, first on 21 Oct 2026, 16:35 UTC. The status did not change between them.
Study data updated · source update from Europe PMC
Version 1
21 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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