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Study · Ex vivo tissue · rat · 2011

2 results

Effect of short peptides on expression of signaling molecules in organotypic pineal cell culture.

Khavinson VKh, Linkova NS, Chalisova NI, Dudkov AV, Koncevaya EA

Bulletin of experimental biology and medicine1 Nov 2011Cited by 1 (Europe PMC)

PMID22803060 (opens in a new tab)DOI10.1007/s10517-011-1473-y (opens in a new tab)PepBankPUB-22803060
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In organotypic pineal gland culture from rats, Ala-Glu-Asp-Gly stimulated synthesis of CGRP by pinealocytes; the effect was seen only with this peptide.

    In plain wordsIn lab-cultured rat pineal tissue, Epitalon raised CGRP production by pineal cells; the other tested peptides did not.

    Peptide
    Epitalon
    Outcome
    IncreaseCGRP synthesis by pinealocytes
    Study

    ratn: not reported in source

    Organotypic pineal gland culture from 3-month-old rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The synthesis of transcription factor CGRP by pinealocytes was stimulated only by Ala-Glu-Asp-Gly.
    1 context sentence
    Summary · context
    We demonstrated the influence of short peptides on the expression of signaling molecules in organotypic culture of the pineal gland from 3-month-old rats.
  2. 02LabEx vivo tissueMechanism

    In organotypic rat pineal gland culture, Glu-Asp-Arg did not stimulate CGRP synthesis, which increased only with Ala-Glu-Asp-Gly.

    In plain wordsIn lab tests with rat pineal tissue, Glu-Asp-Arg did not stimulate CGRP synthesis. Only Ala-Glu-Asp-Gly stimulated it.

    Peptide
    Pinealon
    Outcome
    No significant changeCGRP synthesis
    Study

    ratn: not reported in source

    Organotypic pineal gland culture
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The synthesis of transcription factor CGRP by pinealocytes was stimulated only by Ala-Glu-Asp-Gly.
    2 context sentences
    Summary · context
    These peptides as well as Glu-Asp-Arg and Lys-Glu do not affect the expression of apoptosis marker AIF.
    Summary · context
    We demonstrated the influence of short peptides on the expression of signaling molecules in organotypic culture of the pineal gland from 3-month-old rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 14Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 11 times, first on 14 Oct 2026, 05:02 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    14 Oct 2026, 01:46 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    9 Oct 2026, 18:17 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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