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Study · Ex vivo tissue · 2011

6 results

Peptidegic stimulation of differentiation of pineal immune cells.

Linkova NS, Khavinson VKh, Chalisova NI, Katanugina AS, Koncevaya EA

Bulletin of experimental biology and medicine1 Nov 2011Cited by 2 (Europe PMC)

PMID22803057 (opens in a new tab)DOI10.1007/s10517-011-1470-1 (opens in a new tab)PepBankPUB-22803057
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In organotypic pineal gland culture, epithalon stimulated differentiation of pineal immune cells towards B cells.

    In plain wordsIn lab-cultured pineal gland tissue, epithalon pushed immune cells to develop into B cells.

    Peptide
    Epitalon
    Outcome
    IncreaseDifferentiation of pineal immune cells towards B cells
    Study

    n: not reported in source

    Organotypic culture of pineal gland
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    tetrapeptide epithalon stimulated their differentiation towards B cells.
    1 context sentence
    Summary · context
    We studied cell composition of the pineal lymphoid tissue and the effect of peptides on its differentiation and proliferation capacity.
  2. 02LabEx vivo tissueMechanism

    In pineal gland organotypic culture, vesugen did not affect immune cell differentiation capacity.

    In plain wordsIn lab tests, vesugen did not change the ability of pineal immune cells to differentiate.

    Peptide
    Vesugen (KED)
    Outcome
    No significant changeImmune cell differentiation capacity
    Study

    n: not reported in source

    pineal gland organotypic culture
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tripeptide vesugen had no effect on differentiation capacity of immune cells of the pineal gland
    2 context sentences
    Summary · context
    We studied cell composition of the pineal lymphoid tissue and the effect of peptides on its differentiation and proliferation capacity.
    Summary · context
    It was shown that the lymphoid component of the pineal gland in organotypic culture is primarily presented by low-differentiated CD5(+)-lymphocytes, while mature T and B cells are less abundant.
  3. 03LabEx vivo tissueMechanism

    In pineal gland organotypic culture, vesugen enhanced immune cell proliferation potential.

    In plain wordsIn lab tests, vesugen increased the ability of pineal immune cells to multiply.

    Peptide
    Vesugen (KED)
    Outcome
    IncreaseImmune cell proliferation potential
    Study

    n: not reported in source

    pineal gland organotypic culture
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tripeptide vesugen had no effect on differentiation capacity of immune cells of the pineal gland, but enhanced their proliferation potential.
    2 context sentences
    Summary · context
    We studied cell composition of the pineal lymphoid tissue and the effect of peptides on its differentiation and proliferation capacity.
    Summary · context
    It was shown that the lymphoid component of the pineal gland in organotypic culture is primarily presented by low-differentiated CD5(+)-lymphocytes, while mature T and B cells are less abundant.
  4. 04LabEx vivo tissueMechanism

    In pineal organotypic cultures, Vilon stimulated precursor differentiation into T-helper cells.

    In plain wordsIn lab tests, Vilon increased precursor differentiation into T-helper immune cells.

    Peptide
    Vilon (KE)
    Outcome
    IncreaseT-helper differentiation
    Study

    n: not reported in source

    Pineal gland organotypic culture
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Dipeptide vilon stimulates differentiation of precursors into T-helpers, cytotoxic T lymphocytes, and B cells, while tetrapeptide epithalon stimulated their differentiation towards B cells.
    1 context sentence
    Summary · context
    It was shown that the lymphoid component of the pineal gland in organotypic culture is primarily presented by low-differentiated CD5(+)-lymphocytes, while mature T and B cells are less abundant.
  5. 05LabEx vivo tissueMechanism

    In pineal organotypic cultures, Vilon stimulated precursor differentiation into cytotoxic T lymphocytes.

    In plain wordsIn lab tests, Vilon increased precursor differentiation into cytotoxic T immune cells.

    Peptide
    Vilon (KE)
    Outcome
    IncreaseCytotoxic T-lymphocyte differentiation
    Study

    n: not reported in source

    Pineal gland organotypic culture
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Dipeptide vilon stimulates differentiation of precursors into T-helpers, cytotoxic T lymphocytes, and B cells, while tetrapeptide epithalon stimulated their differentiation towards B cells.
    1 context sentence
    Summary · context
    It was shown that the lymphoid component of the pineal gland in organotypic culture is primarily presented by low-differentiated CD5(+)-lymphocytes, while mature T and B cells are less abundant.
  6. 06LabEx vivo tissueMechanism

    In pineal organotypic cultures, Vilon stimulated precursor differentiation into B cells.

    In plain wordsIn lab tests, Vilon increased precursor differentiation into B immune cells.

    Peptide
    Vilon (KE)
    Outcome
    IncreaseB-cell differentiation
    Study

    n: not reported in source

    Pineal gland organotypic culture
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Dipeptide vilon stimulates differentiation of precursors into T-helpers, cytotoxic T lymphocytes, and B cells, while tetrapeptide epithalon stimulated their differentiation towards B cells.
    1 context sentence
    Summary · context
    It was shown that the lymphoid component of the pineal gland in organotypic culture is primarily presented by low-differentiated CD5(+)-lymphocytes, while mature T and B cells are less abundant.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 5 to 11Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 7 times, first on 21 Oct 2026, 17:05 UTC. The status did not change between them.

    Study results updated

  2. Versions 3 to 4

    21 Oct 2026, 16:35 UTC

    The same notice was added 2 times, first on 21 Oct 2026, 16:35 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  3. Version 2

    9 Oct 2026, 18:17 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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