In rats under water immersion restraint stress, GHRP‑6 injected into the peritoneum before stress prevented gastric mucosal lesions.
In plain wordsIn rats under stress, GHRP‑6 injected into the belly before the stress protected the stomach lining from damage.
- Peptide
- GHRP-6
- Outcome
- DecreaseGastric mucosal lesions with intraperitoneal GHRP-6
- Study
Wistar ratn: not reported in source
Water immersion restraint stress gastric lesion- Outcome group
- Gastrointestinal protection · Gastrointestinal
- Studied dose
- Dose not stated · intraperitonealAs given in this study (Wistar rat).
Source sentences
The mucosal lesions were prevented by prior injection of GHRP-6 via IP did, but not via ICV, suggesting that the protection is peripheral, although a sudden injection is not equivalent to a physiological release and uptake, which eventually may affect the vagal center.
2 context sentences(design, population, supporting numbers)
Male Wistar rats were subjected to conscious or unconscious (anesthetized) WRS, simple restraint (SR), free swimming (FS), non-water fluid immersion, immersion without water contact, or rats were placed in a cage surrounded by sand.
GHRP-6 was injected [intraperitoneal (IP) or intracerebroventricular (ICV)] 2 h before the onset of stress to observe its potential prevention of the mucosal lesion.