Role of thymulin on the somatotropic axis in vivo.

Reggiani PC, Martines EV, Camihort GA, Poch B, Goya RG, Cónsole GM

Life sciences8 Jul 2012Cited by 1 (Europe PMC)

PMID22781709DOI10.1016/j.lfs.2012.06.037PepBankPUB-22781709

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone8

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

01AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism
In C57BL/6 mice, thymulin immunoneutralization significantly decreased body weight gain versus normal rabbit serum.
In plain wordsIn mice, blocking thymulin significantly decreased weight gain compared with normal rabbit serum.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseBody weight gain after immunoneutralization
Study
mousen: not reported in source
C57BL/6 mice
Comparator
Normal rabbit serum
Outcome group
Body weight · Endocrine and hormones
Source sentences
Summary
Thymulin immunoneutralization induced a significant decrease in BW gain, serum GH and somatotrope cell density as well as an increase in somatotrope cell size.
1 context sentence(design, population, supporting numbers)
Summary · context
Immunoneutralization of thymulin was done from postnatal day 1 to 35 by i.p. injections of rabbit anti-thymulin serum (α-FTS) and normal rabbit serum (NRS) in controls.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-2278170901
02AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism
In C57BL/6 mice, thymulin immunoneutralization significantly decreased serum growth hormone versus normal rabbit serum.
In plain wordsIn mice, blocking thymulin significantly decreased blood growth hormone compared with normal rabbit serum.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseSerum growth hormone
Study
mousen: not reported in source
C57BL/6 mice
Comparator
Normal rabbit serum
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Thymulin immunoneutralization induced a significant decrease in BW gain, serum GH and somatotrope cell density as well as an increase in somatotrope cell size.
1 context sentence(design, population, supporting numbers)
Summary · context
Immunoneutralization of thymulin was done from postnatal day 1 to 35 by i.p. injections of rabbit anti-thymulin serum (α-FTS) and normal rabbit serum (NRS) in controls.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-2278170902
03AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism
In C57BL/6 mice, thymulin immunoneutralization significantly decreased somatotrope cell density versus normal rabbit serum.
In plain wordsIn mice, blocking thymulin significantly decreased growth hormone cell density compared with normal rabbit serum.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseSomatotrope cell density after immunoneutralization
Study
mousen: not reported in source
C57BL/6 mice
Comparator
Normal rabbit serum
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Thymulin immunoneutralization induced a significant decrease in BW gain, serum GH and somatotrope cell density as well as an increase in somatotrope cell size.
1 context sentence(design, population, supporting numbers)
Summary · context
Immunoneutralization of thymulin was done from postnatal day 1 to 35 by i.p. injections of rabbit anti-thymulin serum (α-FTS) and normal rabbit serum (NRS) in controls.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-2278170903
04AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism
In C57BL/6 mice, thymulin immunoneutralization increased somatotrope cell size versus normal rabbit serum.
In plain wordsIn mice, blocking thymulin increased growth hormone cell size compared with normal rabbit serum.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseSomatotrope cell size
Study
mousen: not reported in source
C57BL/6 mice
Comparator
Normal rabbit serum
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Thymulin immunoneutralization induced a significant decrease in BW gain, serum GH and somatotrope cell density as well as an increase in somatotrope cell size.
1 context sentence(design, population, supporting numbers)
Summary · context
Immunoneutralization of thymulin was done from postnatal day 1 to 35 by i.p. injections of rabbit anti-thymulin serum (α-FTS) and normal rabbit serum (NRS) in controls.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-2278170904
05AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism
In nu/nu mice, neonatal thymulin gene therapy markedly increased body weight gain versus the control vector.
In plain wordsIn nude mice, thymulin gene therapy markedly increased weight gain compared with the control vector.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseBody weight gain after gene therapy
Study
mousen: not reported in source
nu/nu mice
Comparator
RAd-GFP control vector
Outcome group
Body weight · Endocrine and hormones
Source sentences
Summary
NTGT markedly increased BW gain, serum thymulin (P<0.01) and somatotrope cell and volume density in nu/nu mice.
1 context sentence(design, population, supporting numbers)
Summary · context
NTGT was implemented in nudes using an adenoviral vector expressing a synthetic gene for thymulin (RAd-FTS). On postnatal day 1, heterozygous (nu/+) and homozygous (nu/nu) pups received a single bilateral i.m. injection either RAd-FTS or RAd-GFP (a control vector expressing green fluorescent protein).
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-2278170905
06AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism
In nu/nu mice, neonatal thymulin gene therapy increased serum thymulin versus the control vector (P<0.01).
In plain wordsIn nude mice, thymulin gene therapy increased blood thymulin compared with the control vector.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseSerum thymulin after gene therapy
Study
mousen: not reported in source
nu/nu mice
Comparator
RAd-GFP control vector
Outcome group
Immune response · Endocrine and hormones
Source sentences
Summary
NTGT markedly increased BW gain, serum thymulin (P<0.01) and somatotrope cell and volume density in nu/nu mice.
1 context sentence(design, population, supporting numbers)
Summary · context
NTGT was implemented in nudes using an adenoviral vector expressing a synthetic gene for thymulin (RAd-FTS). On postnatal day 1, heterozygous (nu/+) and homozygous (nu/nu) pups received a single bilateral i.m. injection either RAd-FTS or RAd-GFP (a control vector expressing green fluorescent protein).
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-2278170906
07AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism
In nu/nu mice, neonatal thymulin gene therapy increased somatotrope cell density versus the control vector.
In plain wordsIn nude mice, thymulin gene therapy increased growth hormone cell density compared with the control vector.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseSomatotrope cell density after gene therapy
Study
mousen: not reported in source
nu/nu mice
Comparator
RAd-GFP control vector
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
NTGT markedly increased BW gain, serum thymulin (P<0.01) and somatotrope cell and volume density in nu/nu mice.
1 context sentence(design, population, supporting numbers)
Summary · context
NTGT was implemented in nudes using an adenoviral vector expressing a synthetic gene for thymulin (RAd-FTS). On postnatal day 1, heterozygous (nu/+) and homozygous (nu/nu) pups received a single bilateral i.m. injection either RAd-FTS or RAd-GFP (a control vector expressing green fluorescent protein).
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-2278170907
08AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism
In nu/nu mice, neonatal thymulin gene therapy increased somatotrope volume density versus the control vector.
In plain wordsIn nude mice, thymulin gene therapy increased growth hormone cell volume density compared with the control vector.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseSomatotrope volume density after gene therapy
Study
mousen: not reported in source
nu/nu mice
Comparator
RAd-GFP control vector
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
NTGT markedly increased BW gain, serum thymulin (P<0.01) and somatotrope cell and volume density in nu/nu mice.
1 context sentence(design, population, supporting numbers)
Summary · context
NTGT was implemented in nudes using an adenoviral vector expressing a synthetic gene for thymulin (RAd-FTS). On postnatal day 1, heterozygous (nu/+) and homozygous (nu/nu) pups received a single bilateral i.m. injection either RAd-FTS or RAd-GFP (a control vector expressing green fluorescent protein).
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-2278170908

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 2
21 Oct 2026, 13:55 UTC
Study data updated · source update from Europe PMC
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

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