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Study · Animal study (in vivo) · mouse · 2014

2 results

NrCAM-regulating neural systems and addiction-related behaviors.

Ishiguro H, Hall FS, Horiuchi Y, Sakurai T, Hishimoto A, Grumet M, Uhl GR, Onaivi ES, Arinami T

Addiction biology11 Jul 2012Cited by 26 (Europe PMC)

PMID22780223 (opens in a new tab)PMCIDPMC3470748 (opens in a new tab)DOI10.1111/j.1369-1600.2012.00469.x (opens in a new tab)PepBankPUB-22780223
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, prolyl-leucyl-glycinamide treatment reproduced at least some alcohol-preference phenotypes, without a stated direction.

    In plain wordsIn mice, prolyl-leucyl-glycinamide treatment affected alcohol preference, but the abstract does not state the direction.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    Direction not reportedAlcohol preference
    Study

    mousen: not reported in source

    Outcome group
    Addiction, withdrawal and alcohol intake · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    An inhibitor of the enzyme, prolyl-leucyl-glycinamide, treatment produced, at least, some of the phenotypes of mice shown in alcohol preference and in anxiety-like behavior.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, prolyl-leucyl-glycinamide treatment reproduced at least some anxiety-like behavioral phenotypes, without a stated direction.

    In plain wordsIn mice, prolyl-leucyl-glycinamide treatment affected anxiety-like behavior, but the abstract does not state the direction.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    Direction not reportedAnxiety-like behavior
    Study

    mousen: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    An inhibitor of the enzyme, prolyl-leucyl-glycinamide, treatment produced, at least, some of the phenotypes of mice shown in alcohol preference and in anxiety-like behavior.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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