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Study · Measured the body's own peptide · 2012

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A preliminary study of the effects of repeated massage on hypothalamic-pituitary-adrenal and immune function in healthy individuals: a study of mechanisms of action and dosage.

Rapaport MH, Schettler P, Bresee C

Journal of alternative and complementary medicine (New York, N.Y.)9 Jul 2012Cited by 55 (Europe PMC)

PMID22775448 (opens in a new tab)PMCIDPMC3419840 (opens in a new tab)DOI10.1089/acm.2011.0071 (opens in a new tab)PepBankPUB-22775448
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelRandomized controlled trialOther

    In healthy young adults, twice-weekly Swedish massage for 5 weeks increased circulating oxytocin levels compared with light touch.

    In plain wordsIn healthy young adults, twice-weekly massage raised the body's own oxytocin levels compared with light touch.

    Peptide
    Oxytocin
    Outcome
    IncreaseCirculating oxytocin level with twice-weekly massage
    Study

    n: not reported in source

    Comparator
    Light touch
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Twice-weekly massage produced a different response pattern with increased OT levels
    2 context sentences
    Summary · context
    The study design was a 5-week comparison of repeated Swedish massage and light touch on oxytocin (OT), arginine-vasopressin (AVP), adrenal corticotropin hormone (ACTH), cortisol (CORT), circulating phenotypic lymphocyte markers, and mitogen-stimulated cytokine function.
    Summary · context
    The study comprised 45 minutes of Swedish massage or light touch, using highly specified and identical protocols, either weekly or twice weekly for 5 weeks.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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