Effect of semax and its C-terminal fragment Pro-Gly-Pro on the expression of VEGF family genes and their receptors in experimental focal ischemia of the rat brain.

Medvedeva EV, Dmitrieva VG, Povarova OV, Limborska SA, Skvortsova VI, Myasoedov NF, Dergunova LV

Journal of molecular neuroscience : MN8 Jul 2012Cited by 11 (Europe PMC)

PMID22772900DOI10.1007/s12031-012-9853-yPepBankPUB-22772900

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats 3 h after pMCAO, Semax and Pro-Gly-Pro activated Vegf-b gene expression most noticeably.
In plain wordsIn rats with brain ischemia, Semax raised activity of the Vegf-b gene 3 hours after the blockage.
Peptide
Semax
Outcome
IncreaseVegf-b expression 3 h after pMCAO
Study
ratn: not reported in source
Permanent middle cerebral artery occlusion (pMCAO), frontoparietal cortex
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The Vegf-b and Vegf-d genes were most affected by the peptides, which resulted in their most noticeable activation at 3 h after pMCAO.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the action of Semax and its C-terminal tripeptide Pro-Gly-Pro on the expression of the VEGF gene family (Vegf-a, Vegf-b, Vegf-c, Vegf-d, and Plgf) and their receptors (Vegfr-1, Vegfr-2, and Vegfr-3) in the frontoparietal cortex region of the rat brain at 3, 24, and 72 h after permanent le…
Report a problemFND-2277290001
02AnimalAnimal study (in vivo)Mechanism
In rats 3 h after pMCAO, Semax and Pro-Gly-Pro activated Vegf-d gene expression most noticeably.
In plain wordsIn rats with brain ischemia, Semax raised activity of the Vegf-d gene 3 hours after the blockage.
Peptide
Semax
Outcome
IncreaseVegf-d expression 3 h after pMCAO
Study
ratn: not reported in source
Permanent middle cerebral artery occlusion (pMCAO), frontoparietal cortex
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The Vegf-b and Vegf-d genes were most affected by the peptides, which resulted in their most noticeable activation at 3 h after pMCAO.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the action of Semax and its C-terminal tripeptide Pro-Gly-Pro on the expression of the VEGF gene family (Vegf-a, Vegf-b, Vegf-c, Vegf-d, and Plgf) and their receptors (Vegfr-1, Vegfr-2, and Vegfr-3) in the frontoparietal cortex region of the rat brain at 3, 24, and 72 h after permanent le…
Report a problemFND-2277290002
03AnimalAnimal study (in vivo)Mechanism
In rats after 72 h of treatment, Semax and Pro-Gly-Pro considerably decreased Vegf-d transcript levels.
In plain wordsIn rats with brain ischemia, Semax lowered Vegf-d gene activity after 72 hours of treatment.
Peptide
Semax
Outcome
DecreaseVegf-d expression 72 h after pMCAO
Study
ratn: not reported in source
Permanent middle cerebral artery occlusion (pMCAO), frontoparietal cortex
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The level of Vegf-d transcripts decreased considerably
2 context sentences(design, population, supporting numbers)
Summary · context
after 72 h of treatment with each of the peptides.
Summary · context
We studied the action of Semax and its C-terminal tripeptide Pro-Gly-Pro on the expression of the VEGF gene family (Vegf-a, Vegf-b, Vegf-c, Vegf-d, and Plgf) and their receptors (Vegfr-1, Vegfr-2, and Vegfr-3) in the frontoparietal cortex region of the rat brain at 3, 24, and 72 h after permanent le…
Report a problemFND-2277290003
04AnimalAnimal study (in vivo)Mechanism
In rats after 72 h of treatment, Semax and Pro-Gly-Pro significantly increased Vegf-b mRNA levels.
In plain wordsIn rats with brain ischemia, Semax raised Vegf-b gene activity after 72 hours of treatment.
Peptide
Semax
Outcome
IncreaseVegf-b expression 72 h after pMCAO
Study
ratn: not reported in source
Permanent middle cerebral artery occlusion (pMCAO), frontoparietal cortex
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
whereas the mRNA level of the Vegf-b gene was significantly increased after 72 h of treatment with each of the peptides.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the action of Semax and its C-terminal tripeptide Pro-Gly-Pro on the expression of the VEGF gene family (Vegf-a, Vegf-b, Vegf-c, Vegf-d, and Plgf) and their receptors (Vegfr-1, Vegfr-2, and Vegfr-3) in the frontoparietal cortex region of the rat brain at 3, 24, and 72 h after permanent le…
Report a problemFND-2277290004
05AnimalAnimal study (in vivo)Mechanism
In rats, the effects of Semax and Pro-Gly-Pro on Vegf-b and Vegf-d expression were the opposite of the action of ischemia.
In plain wordsIn rats with brain ischemia, Semax changed Vegf-b and Vegf-d gene activity in the opposite direction to ischemia.
Peptide
Semax
Outcome
MixedDirection of Vegf-b and Vegf-d effects compared with ischemia
Study
ratn: not reported in source
Permanent middle cerebral artery occlusion (pMCAO), frontoparietal cortex
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In addition, the effects of the peptides on the expression of the Vegf-b and Vegf-d genes were the opposite of the action of ischemia.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the action of Semax and its C-terminal tripeptide Pro-Gly-Pro on the expression of the VEGF gene family (Vegf-a, Vegf-b, Vegf-c, Vegf-d, and Plgf) and their receptors (Vegfr-1, Vegfr-2, and Vegfr-3) in the frontoparietal cortex region of the rat brain at 3, 24, and 72 h after permanent le…
Report a problemFND-2277290005

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 19:08 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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