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Study · Randomized controlled trial · n = 57 · 2012

3 results

The influence of oxytocin administration on responses to infant faces and potential moderation by OXTR genotype.

Marsh AA, Yu HH, Pine DS, Gorodetsky EK, Goldman D, Blair RJ

Psychopharmacology5 Jul 2012Cited by 59 (Europe PMC)

PMID22763666 (opens in a new tab)PMCIDPMC3500580 (opens in a new tab)DOI10.1007/s00213-012-2775-0 (opens in a new tab)PepBankPUB-22763666
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy adults, intranasal oxytocin increased preference for infant faces compared with placebo.

    In plain wordsIn healthy adults, oxytocin made infant faces seem more appealing than placebo did.

    Peptide
    Oxytocin
    Outcome
    IncreasePreference for infant faces
    Study

    n = 57

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Infants' faces were more strongly preferred following oxytocin inhalation relative to placebo.
    2 context sentences
    Summary · context
    A double-blind, between-groups design was used, with 57 genotyped volunteers randomly assigned to receive intranasally administered oxytocin or placebo.
    Summary · context
    Fifty minutes following the administration of oxytocin or placebo, participants viewed infants' and adults' faces showing neutral expressions and assessed how appealing they found each face.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy adults, intranasal oxytocin did not change preference for adults' faces compared with placebo.

    In plain wordsIn healthy adults, oxytocin did not change how appealing adult faces seemed compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changePreference for adults' faces
    Study

    n = 57

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Parallel effects were not seen for adults' faces.
    2 context sentences
    Summary · context
    A double-blind, between-groups design was used, with 57 genotyped volunteers randomly assigned to receive intranasally administered oxytocin or placebo.
    Summary · context
    Fifty minutes following the administration of oxytocin or placebo, participants viewed infants' and adults' faces showing neutral expressions and assessed how appealing they found each face.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy adults, the oxytocin-induced preference for infant faces was seen only in participants homozygous for the OXTR rs53576G allele.

    In plain wordsIn healthy adults, oxytocin raised preference for infant faces only in people with two copies of one gene variant.

    Peptide
    Oxytocin
    Outcome
    IncreasePreference for infant faces in rs53576G homozygotes
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    When participants were separated according to genotype, this effect was only observed for participants homozygous for the rs53576G allele.
    2 context sentences
    Summary · context
    A double-blind, between-groups design was used, with 57 genotyped volunteers randomly assigned to receive intranasally administered oxytocin or placebo.
    Summary · context
    Fifty minutes following the administration of oxytocin or placebo, participants viewed infants' and adults' faces showing neutral expressions and assessed how appealing they found each face.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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