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Study · Animal study (in vivo) · mouse · 2012

4 results

Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.

De Jonghe BC, Hayes MR, Zimmer DJ, Kanoski SE, Grill HJ, Bence KK

American journal of physiology. Endocrinology and metabolism3 Jul 2012Cited by 24 (Europe PMC)

PMID22761160 (opens in a new tab)PMCIDPMC3468506 (opens in a new tab)DOI10.1152/ajpendo.00009.2012 (opens in a new tab)PepBankPUB-22761160
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In POMC-specific PTP1B knockout mice, hindbrain MTII suppressed food intake more strongly than in WT mice.

    In plain wordsIn mice lacking PTP1B in certain brain cells, MTII reduced food intake more than in normal mice.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake suppression by hindbrain MTII
    Study

    mousen: not reported in source

    POMC-Ptp1b-/- (KO) and PTP1Bfl/fl (WT) mice
    Comparator
    WT mice
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.1 and 0.2 nmol · hindbrain (4th ventricle)As given in this study (mouse).

    Source sentences

    Summary
    KO mice were hypersensitive to hindbrain leptin- and MTII-induced food intake and body weight suppression and SPA compared with WT mice.
    1 context sentence
    Summary · context
    Therefore, we examined the effects of hindbrain administration (4th ventricle) of leptin (1.5, 3, and 6 μg) or the melanocortin 3/4R agonist melanotan II (0.1 and 0.2 nmol) in POMC-Ptp1b(-/-) (KO) and control PTP1B(fl/fl) (WT) mice on food intake, body weight, spontaneous physical activity (SPA), an…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In POMC-specific PTP1B knockout mice, hindbrain MTII suppressed body weight more strongly than in WT mice.

    In plain wordsIn mice lacking PTP1B in certain brain cells, MTII lowered body weight more than in normal mice.

    Peptide
    Melanotan II
    Outcome
    DecreaseBody weight suppression by hindbrain MTII
    Study

    mousen: not reported in source

    POMC-Ptp1b-/- (KO) and PTP1Bfl/fl (WT) mice
    Comparator
    WT mice
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    0.1 and 0.2 nmol · hindbrain (4th ventricle)As given in this study (mouse).

    Source sentences

    Summary
    KO mice were hypersensitive to hindbrain leptin- and MTII-induced food intake and body weight suppression and SPA compared with WT mice.
    1 context sentence
    Summary · context
    Therefore, we examined the effects of hindbrain administration (4th ventricle) of leptin (1.5, 3, and 6 μg) or the melanocortin 3/4R agonist melanotan II (0.1 and 0.2 nmol) in POMC-Ptp1b(-/-) (KO) and control PTP1B(fl/fl) (WT) mice on food intake, body weight, spontaneous physical activity (SPA), an…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In POMC-specific PTP1B knockout mice, the SPA response to hindbrain MTII was more sensitive than in WT mice; the direction is not stated.

    In plain wordsIn mice lacking PTP1B in certain brain cells, activity responded more to MTII than in normal mice.

    Peptide
    Melanotan II
    Outcome
    Direction not reportedSpontaneous physical activity (SPA) after hindbrain MTII
    Study

    mousen: not reported in source

    POMC-Ptp1b-/- (KO) and PTP1Bfl/fl (WT) mice
    Comparator
    WT mice
    Outcome group
    Exercise and physical function · Metabolic and weight
    Studied dose
    0.1 and 0.2 nmol · hindbrain (4th ventricle)As given in this study (mouse).

    Source sentences

    Summary
    KO mice were hypersensitive to hindbrain leptin- and MTII-induced food intake and body weight suppression and SPA compared with WT mice.
    1 context sentence
    Summary · context
    Therefore, we examined the effects of hindbrain administration (4th ventricle) of leptin (1.5, 3, and 6 μg) or the melanocortin 3/4R agonist melanotan II (0.1 and 0.2 nmol) in POMC-Ptp1b(-/-) (KO) and control PTP1B(fl/fl) (WT) mice on food intake, body weight, spontaneous physical activity (SPA), an…
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    Hindbrain MTII-induced core temperature increases did not differ between KO and WT mice, unlike the leptin-induced increases.

    In plain wordsIn these mice, MTII changed core temperature to a similar degree in knockout and normal mice.

    Peptide
    Melanotan II
    Outcome
    No significant changeCore temperature after hindbrain MTII
    Study

    mousen: not reported in source

    POMC-Ptp1b-/- (KO) and PTP1Bfl/fl (WT) mice
    Comparator
    WT mice
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    0.1 and 0.2 nmol · hindbrain (4th ventricle)As given in this study (mouse).

    Source sentences

    Summary
    Greater increases in leptin- but not MTII-induced T(C) were also observed in KO vs. WT animals.
    1 context sentence
    Summary · context
    Therefore, we examined the effects of hindbrain administration (4th ventricle) of leptin (1.5, 3, and 6 μg) or the melanocortin 3/4R agonist melanotan II (0.1 and 0.2 nmol) in POMC-Ptp1b(-/-) (KO) and control PTP1B(fl/fl) (WT) mice on food intake, body weight, spontaneous physical activity (SPA), an…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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