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Study · Randomized controlled trial · n = 45 · 2012

2 results

Oxytocin interference in the effects induced by inhalation of 7.5% CO(2) in healthy volunteers.

de Oliveira DC, Chagas MH, Garcia LV, Crippa JA, Zuardi AW

Human psychopharmacology18 Jun 2012Cited by 34 (Europe PMC)

PMID22711428 (opens in a new tab)DOI10.1002/hup.2237 (opens in a new tab)PepBankPUB-22711428
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, intranasal oxytocin prevented the rise in anxiety score that 7.5% CO2 inhalation caused in the placebo group.

    In plain wordsIn healthy volunteers, oxytocin prevented the rise in anxiety that breathing CO2 caused in the placebo group.

    Peptide
    Oxytocin
    Outcome
    DecreaseCO2-induced anxiety score
    Study

    n = 45

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    CO(2) inhalation significantly increased the anxiety score in the PL group compared with the post-air measurement but not in the OT or LZP groups.
    3 context sentences
    Summary · context
    The objective of this study was to assess the acute effect of intranasally administered oxytocin (OT) on subjective states, cardiovascular, and endocrine parameters in healthy volunteers who inhaled 7.5% CO(2) .
    Summary · context
    Forty-five subjects were allocated into three matched groups of subjects who received 24 international units (IU) of OT, 2 mg of lorazepam (LZP), or placebo (PL).
    Summary · context
    The challenge consisted of medical air inhalation for 20 min, 10 min of rest, and CO(2) 7.5% inhalation for 20 min.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers inhaling 7.5% CO2, the other evaluated parameters, including cardiovascular and endocrine measures, were not affected by oxytocin.

    In plain wordsIn healthy volunteers, oxytocin did not change the other measures, including heart rate, blood pressure and cortisol.

    Peptide
    Oxytocin
    Outcome
    No significant changeHeart rate, blood pressure, skin conductance and salivary cortisol
    Study

    n = 45

    Comparator
    Placebo
    Outcome group
    Stress hormones · Whole body
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Other parameters evaluated were not affected by OT.
    4 context sentences
    Summary · context
    Subjective effects were evaluated by self-assessment scales; heart rate, blood pressure, skin conductance, and salivary cortisol were also measured.
    Summary · context
    The objective of this study was to assess the acute effect of intranasally administered oxytocin (OT) on subjective states, cardiovascular, and endocrine parameters in healthy volunteers who inhaled 7.5% CO(2) .
    Summary · context
    Forty-five subjects were allocated into three matched groups of subjects who received 24 international units (IU) of OT, 2 mg of lorazepam (LZP), or placebo (PL).
    Summary · context
    The challenge consisted of medical air inhalation for 20 min, 10 min of rest, and CO(2) 7.5% inhalation for 20 min.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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