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Study · Animal study (in vivo) · rat · 2012

3 results

Correction of long-lasting negative effects of neonatal isolation in white rats using semax.

Volodina MA, Sebentsova EA, Glazova NY, Manchenko DM, Inozemtseva LS, Dolotov OV, Andreeva LA, Levitskaya NG, Kamensky AA, Myasoedov NF

Acta naturae1 Jan 2012Cited by 3 (Europe PMC)

PMID22708068 (opens in a new tab)PMCIDPMC3372995 (opens in a new tab)DOI10.32607/20758251-2012-4-1-86-92 (opens in a new tab)PepBankPUB-22708068
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Summary

Adverse experience during the early postnatal period induces negative alterations in physiological and neurobiological functions, resulting in long-term disorder in animal behavior. The aim of the present work was to study the long-lasting effects of chronic neonatal stress in white rats and to estimate the possibility of their correction using Semax, an analogue of ACTH fragment (4-10). Early neonatal isolation was used as a model of early-life stress. Rat pups were separated from their mothers and littermates for 5 h daily during postnatal days 1-14. The pups of the control group were left undisturbed with the dams. Half of the rats subjected to neonatal isolation received an intranasal injection of Semax at a dose of 50 µg/kg daily, from postnatal day 15 until day 28. The other animals received intranasal vehicle injections daily at the same time points. It was shown that neonatal isolation leads to a delay in physical development, metabolic disturbances, and a decrease in the corticosterone stress response in white rats. These changes were observed during the first two months of life. Semax administration weakened the influence of neonatal isolation on the animals, body weight , reduced metabolic dysfunction, and led to an increase in stress-induced corticosterone release to the control values. So the chronic intranasal administration of Semax after termination of the neonatal isolation procedure diminishes the negative effects of neonatal stress.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In white rats after neonatal isolation, Semax weakened the influence of isolation on body weight.

    In plain wordsIn rats stressed in early life, Semax lessened the effect of the stress on body weight.

    Peptide
    Semax
    Outcome
    Direction not reportedBody weight after neonatal isolation
    Study

    ratn: not reported in source

    Neonatal isolation (early-life stress)
    Comparator
    Intranasal vehicle in isolated rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    50 µg/kg daily · intranasal · from postnatal day 15 until day 28As given in this study (rat).

    Source sentences

    Summary
    Semax administration weakened the influence of neonatal isolation on the animals, body weight
    4 context sentences
    Summary · context
    Early neonatal isolation was used as a model of early-life stress.
    Summary · context
    Rat pups were separated from their mothers and littermates for 5 h daily during postnatal days 1-14.
    Summary · context
    Half of the rats subjected to neonatal isolation received an intranasal injection of Semax at a dose of 50 µg/kg daily, from postnatal day 15 until day 28.
    Summary · context
    The other animals received intranasal vehicle injections daily at the same time points.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In white rats after neonatal isolation, Semax reduced metabolic dysfunction.

    In plain wordsIn rats stressed in early life, Semax reduced metabolic problems caused by the stress.

    Peptide
    Semax
    Outcome
    DecreaseMetabolic dysfunction after neonatal isolation
    Study

    ratn: not reported in source

    Neonatal isolation (early-life stress)
    Comparator
    Intranasal vehicle in isolated rats
    Outcome group
    Cardiometabolic risk factors · Metabolic and weight
    Studied dose
    50 µg/kg daily · intranasal · from postnatal day 15 until day 28As given in this study (rat).

    Source sentences

    Summary
    reduced metabolic dysfunction
    4 context sentences
    Summary · context
    Early neonatal isolation was used as a model of early-life stress.
    Summary · context
    Rat pups were separated from their mothers and littermates for 5 h daily during postnatal days 1-14.
    Summary · context
    Half of the rats subjected to neonatal isolation received an intranasal injection of Semax at a dose of 50 µg/kg daily, from postnatal day 15 until day 28.
    Summary · context
    The other animals received intranasal vehicle injections daily at the same time points.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In white rats after neonatal isolation, Semax increased the stress-induced corticosterone release to control values.

    In plain wordsIn rats stressed in early life, Semax restored the stress hormone response to control levels.

    Peptide
    Semax
    Outcome
    IncreaseStress-induced corticosterone release
    Study

    ratn: not reported in source

    Neonatal isolation (early-life stress)
    Comparator
    Intranasal vehicle in isolated rats
    Outcome group
    Anxiety and mood · Endocrine and hormones
    Studied dose
    50 µg/kg daily · intranasal · from postnatal day 15 until day 28As given in this study (rat).

    Source sentences

    Summary
    led to an increase in stress-induced corticosterone release to the control values.
    4 context sentences
    Summary · context
    Early neonatal isolation was used as a model of early-life stress.
    Summary · context
    Rat pups were separated from their mothers and littermates for 5 h daily during postnatal days 1-14.
    Summary · context
    Half of the rats subjected to neonatal isolation received an intranasal injection of Semax at a dose of 50 µg/kg daily, from postnatal day 15 until day 28.
    Summary · context
    The other animals received intranasal vehicle injections daily at the same time points.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 10:21 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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