Skip to content

Study · Not a test of the peptide alone · 2012

3 results

[Ulinastatin combined with thymosin α1 for treatment of severe sepsis: a histopathological observation in rats].

Guo J, Deng Q, Guo X, Liu S, Zhang Y, He Z, Lin H

Nan fang yi ke da xue xue bao = Journal of Southern Medical University1 Jun 2012Cited by 1 (Europe PMC)

PMID22699064 (opens in a new tab)PepBankPUB-22699064
Publisher pageAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 01AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome

    In rats with severe sepsis, the combination of ulinastatin and thymosin alpha‑1 lowered the mortality rate.

    In plain wordsIn rats with severe sepsis, ulinastatin plus thymosin alpha‑1 lowered the death rate.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseMortality rate
    Study

    ratn: not reported in source

    cecal ligation and puncture sepsis
    Outcome group
    Mortality · Infection

    Source sentences

    Summary
    The mortality rate of the septic rats in the combined treatment group was decreased significantly (P=0.0325).
    2 context sentences
    Summary · context
    Normal Wistar rats were subject to cecal ligation and puncture (CLP) to establish models of severe sepsis.
    Summary · context
    The rats were then randomized into 4 groups for treatment with saline (control), ulinastatin, thymosin α1, or the combination of the latter two injected through the caudal vein or subcutaneously at 6, 24, 48 and 72 h after modeling.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 02AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome

    In rats with severe sepsis, organ damage was mildest with ulinastatin plus thymosin alpha‑1, moderate with a single drug and most severe in controls.

    In plain wordsIn rats with severe sepsis, organ damage was mildest with ulinastatin plus thymosin alpha‑1, moderate with one drug and worst in untreated rats.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseOrgan damage on pathological examination
    Study

    ratn: not reported in source

    cecal ligation and puncture sepsis
    Comparator
    Saline control and single drugs
    Outcome group
    Organ injury · Infection

    Source sentences

    Summary
    The control group showed the most severe organ damage, which was moderate in single drug treatment group and the mildest in combined treatment group.
    2 context sentences
    Summary · context
    Normal Wistar rats were subject to cecal ligation and puncture (CLP) to establish models of severe sepsis.
    Summary · context
    The rats were then randomized into 4 groups for treatment with saline (control), ulinastatin, thymosin α1, or the combination of the latter two injected through the caudal vein or subcutaneously at 6, 24, 48 and 72 h after modeling.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  3. 03AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome

    In rats with severe sepsis, ulinastatin plus thymosin alpha‑1 significantly reduced spleen cell apoptosis compared with controls.

    In plain wordsIn rats with severe sepsis, ulinastatin plus thymosin alpha‑1 reduced spleen cell death compared with untreated rats.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseSpleen cell apoptosis
    Study

    ratn: not reported in source

    cecal ligation and puncture sepsis
    Comparator
    Saline control
    Outcome group
    Organ injury · Infection

    Source sentences

    Summary
    Obvious spleen cell apoptosis was found in the control group, and was significantly ameliorated in the combined treatment group[(47.4∓10.9)% vs (39.3∓11.4)%, P=0.0000].
    2 context sentences
    Summary · context
    Normal Wistar rats were subject to cecal ligation and puncture (CLP) to establish models of severe sepsis.
    Summary · context
    The rats were then randomized into 4 groups for treatment with saline (control), ulinastatin, thymosin α1, or the combination of the latter two injected through the caudal vein or subcutaneously at 6, 24, 48 and 72 h after modeling.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.