[Effects of recombinant mechano-dependent growth factor against the background of chronic alcoholisation in rats].

Lysenko EA, Turtikova OV, Morozkina EV, Khotchenkov VP, Popov VO, Shenkman BS

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova1 Feb 2012Cited by 1 (Europe PMC)

PMID22650072DOI10.1007/s11055-013-9837-6PepBankPUB-22650072

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In alcoholised rats, recombinant mechano-growth factor increased the proliferative activity of myogenic precursors.
In plain wordsIn rats given alcohol over time, MGF raised the growth of muscle precursor cells.
Peptide
MGF / PEG-MGF
Outcome
IncreaseProliferative activity of myogenic precursors
Study
ratn: not reported in source
Chronic alcoholisation
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
The mechano-growth factor abministration increased the proliferate activity of the myogenic precursors and restored the myonuclei pool.
1 context sentence(design, population, supporting numbers)
Summary · context
In alcoholised rats, proliferation of satellite cells consistently decreased as well as the number of myonuclei, while phosphorylation of p90RSK became reduced.
Report a problemFND-2265007201
02AnimalAnimal study (in vivo)Efficacy outcome
In alcoholised rats, recombinant mechano-growth factor restored the myonuclei pool.
In plain wordsIn rats given alcohol over time, MGF restored the number of muscle cell nuclei.
Peptide
MGF / PEG-MGF
Outcome
IncreaseMyonuclei pool
Study
ratn: not reported in source
Chronic alcoholisation
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
The mechano-growth factor abministration increased the proliferate activity of the myogenic precursors and restored the myonuclei pool.
1 context sentence(design, population, supporting numbers)
Summary · context
In alcoholised rats, proliferation of satellite cells consistently decreased as well as the number of myonuclei, while phosphorylation of p90RSK became reduced.
Report a problemFND-2265007202
03AnimalAnimal study (in vivo)Efficacy outcome
In alcoholised rats, phosphorylation of p90RSK increased after mechano-growth factor administration.
In plain wordsIn rats given alcohol over time, MGF raised activity of the p90RSK signal protein.
Peptide
MGF / PEG-MGF
Outcome
Increasep90RSK phosphorylation
Study
ratn: not reported in source
Chronic alcoholisation
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
The mechano-growth factor abministration increased the proliferate activity of the myogenic precursors and restored the myonuclei pool. Phosphorylation of p90RSK increased too.
1 context sentence(design, population, supporting numbers)
Summary · context
In alcoholised rats, proliferation of satellite cells consistently decreased as well as the number of myonuclei, while phosphorylation of p90RSK became reduced.
Report a problemFND-2265007203

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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