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Study · Randomized controlled trial · n = 15 · 2013

2 results

Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex.

Sripada CS, Phan KL, Labuschagne I, Welsh R, Nathan PJ, Wood AG

The international journal of neuropsychopharmacology30 May 2012Cited by 148 (Europe PMC)

PMID22647521 (opens in a new tab)DOI10.1017/s1461145712000533 (opens in a new tab)PepBankPUB-22647521
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In healthy volunteers, intranasal oxytocin increased resting-state connectivity between both amygdalae and rostral medial frontal cortex versus placebo.

    In plain wordsIn healthy volunteers, oxytocin increased the connection between the amygdala and a frontal brain area at rest, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseAmygdala to rostral medial frontal cortex connectivity
    Study

    n = 15

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    OXT significantly increased connectivity between both amygdalae and rostral medial frontal cortex (rmFC)
    1 context sentence
    Summary · context
    In a randomized, double-blind, cross-over design, 15 volunteers received intranasal OXT or placebo prior to resting-state functional magnetic resonance imaging.
  2. 02HumanRandomized controlled trialMechanism

    In healthy volunteers, intranasal oxytocin had only negligible effects on amygdala coupling with other brain regions versus placebo.

    In plain wordsIn healthy volunteers, oxytocin had almost no effect on amygdala connections to other brain regions, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeAmygdala coupling with other brain regions
    Study

    n = 15

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    while having only negligible effects on coupling with other brain regions.
    1 context sentence
    Summary · context
    In a randomized, double-blind, cross-over design, 15 volunteers received intranasal OXT or placebo prior to resting-state functional magnetic resonance imaging.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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