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Study · Animal study (in vivo) · rat · 2012

2 results

Region-specific differences in brain melanocortin receptors in rats of the lean phenotype.

Shukla C, Britton SL, Koch LG, Novak CM

Neuroreport1 Jul 2012Cited by 13 (Europe PMC)

PMID22643233 (opens in a new tab)PMCIDPMC3831884 (opens in a new tab)DOI10.1097/wnr.0b013e328354f5c1 (opens in a new tab)PepBankPUB-22643233
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, melanotan II microinjected into the PVN region induced a dose-dependent increase in physical activity.

    In plain wordsIn rats, melanotan II injected into a brain region called the PVN raised physical activity, more with higher doses.

    Peptide
    Melanotan II
    Outcome
    IncreasePhysical activity after intra-PVN melanotan II
    Study

    ratn: not reported in source

    Outcome group
    Exercise and physical function · Metabolic and weight
    Studied dose
    Dose not stated · microinjection into the paraventricular nucleus regionAs given in this study (rat).

    Source sentences

    Summary
    Intra-PVN melanotan II induced a dose-dependent increase in PA
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, the melanotan II-induced increase in physical activity was greater in high-activity rats than in low-activity rats.

    In plain wordsIn rats, melanotan II raised activity more in naturally high-activity rats than in low-activity rats.

    Peptide
    Melanotan II
    Outcome
    IncreasePhysical activity response to intra-PVN melanotan II, high- versus low-activity rats
    Study

    ratn: not reported in source

    Comparator
    Low-activity rats
    Outcome group
    Exercise and physical function · Metabolic and weight
    Studied dose
    Dose not stated · microinjection into the paraventricular nucleus regionAs given in this study (rat).

    Source sentences

    Summary
    this effect was greater in high-activity rats compared with low-activity rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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