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Study · Animal study (in vivo) · mouse · 2012

10 results

Intermittent PTH (1-34) injection rescues the retarded skeletal development and postnatal lethality of mice mimicking human achondroplasia and thanatophoric dysplasia.

Xie Y, Su N, Jin M, Qi H, Yang J, Li C, Du X, Luo F, Chen B, Shen Y, Huang H, Xian CJ, Deng C, Chen L

Human molecular genetics24 May 2012Cited by 36 (Europe PMC)

PMID22634226 (opens in a new tab)DOI10.1093/hmg/dds181 (opens in a new tab)PepBankPUB-22634226
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In TDII mice, intermittent PTH injection rescued the lethal phenotype.

    In plain wordsIn mice with TDII, PTH injections rescued the lethal phenotype.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseLethal phenotype
    Study

    micen: not reported in source

    TDII mice
    Outcome group
    Mortality · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We here showed that systemic intermittent PTH (1-34) injection can rescue the lethal phenotype of TD type II (TDII) mice
    1 context sentence
    Summary · context
    We here showed that systemic intermittent PTH (1-34) injection can rescue the lethal phenotype of TD type II (TDII) mice and significantly alleviate the retarded skeleton development of ACH mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ACH mice, intermittent PTH injection significantly alleviated retarded skeletal development.

    In plain wordsIn mice with ACH, PTH injections improved delayed skeletal development.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseRetarded skeletal development
    Study

    micen: not reported in source

    ACH mice
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We here showed that systemic intermittent PTH (1-34) injection can rescue the lethal phenotype of TD type II (TDII) mice and significantly alleviate the retarded skeleton development of ACH mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ACH mice, PTH treatment increased naso-anal length compared with ACH controls.

    In plain wordsIn mice with ACH, PTH increased body length compared with ACH controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseNaso-anal length
    Study

    micen: not reported in source

    ACH mice
    Comparator
    ACH control mice
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    PTH-treated ACH mice had longer naso-anal length than ACH control mice, and the bone lengths of humeri and tibiae were rescued to be comparable with those of wild-type control mice.
    1 context sentence
    Summary · context
    We here showed that systemic intermittent PTH (1-34) injection can rescue the lethal phenotype of TD type II (TDII) mice and significantly alleviate the retarded skeleton development of ACH mice.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In ACH mice, PTH treatment restored humerus length to a level comparable with wild-type controls.

    In plain wordsIn mice with ACH, PTH restored upper-arm bone length to a level comparable with normal controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    Not applicableHumerus length
    Study

    micen: not reported in source

    ACH mice
    Comparator
    Wild-type control mice
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    PTH-treated ACH mice had longer naso-anal length than ACH control mice, and the bone lengths of humeri and tibiae were rescued to be comparable with those of wild-type control mice.
    1 context sentence
    Summary · context
    We here showed that systemic intermittent PTH (1-34) injection can rescue the lethal phenotype of TD type II (TDII) mice and significantly alleviate the retarded skeleton development of ACH mice.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In ACH mice, PTH treatment restored tibia length to a level comparable with wild-type controls.

    In plain wordsIn mice with ACH, PTH restored shinbone length to a level comparable with normal controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    Not applicableTibia length
    Study

    micen: not reported in source

    ACH mice
    Comparator
    Wild-type control mice
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    PTH-treated ACH mice had longer naso-anal length than ACH control mice, and the bone lengths of humeri and tibiae were rescued to be comparable with those of wild-type control mice.
    1 context sentence
    Summary · context
    We here showed that systemic intermittent PTH (1-34) injection can rescue the lethal phenotype of TD type II (TDII) mice and significantly alleviate the retarded skeleton development of ACH mice.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In ACH mice, PTH treatment partially corrected premature fusion of cranial synchondroses.

    In plain wordsIn mice with ACH, PTH partially corrected premature fusion of skull growth joints.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreasePremature cranial synchondrosis fusion
    Study

    micen: not reported in source

    ACH mice
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our study also found that the premature fusion of cranial synchondroses in ACH mice was partially corrected after the PTH (1-34) treatment,
    1 context sentence
    Summary · context
    We here showed that systemic intermittent PTH (1-34) injection can rescue the lethal phenotype of TD type II (TDII) mice and significantly alleviate the retarded skeleton development of ACH mice.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In ACH mice, PTH treatment improved osteopenia.

    In plain wordsIn mice with ACH, PTH improved low bone mass.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseOsteopenia
    Study

    micen: not reported in source

    ACH mice
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, we found that the PTH treatment can improve the osteopenia and bone structure of ACH mice.
    1 context sentence
    Summary · context
    We here showed that systemic intermittent PTH (1-34) injection can rescue the lethal phenotype of TD type II (TDII) mice and significantly alleviate the retarded skeleton development of ACH mice.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In ACH mice, PTH treatment improved bone structure.

    In plain wordsIn mice with ACH, PTH improved bone structure.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBone structure
    Study

    micen: not reported in source

    ACH mice
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, we found that the PTH treatment can improve the osteopenia and bone structure of ACH mice.
    1 context sentence
    Summary · context
    We here showed that systemic intermittent PTH (1-34) injection can rescue the lethal phenotype of TD type II (TDII) mice and significantly alleviate the retarded skeleton development of ACH mice.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In ACH and TDII mice, PTH treatment was associated with increased PTHrP expression.

    In plain wordsIn mice with ACH and TDII, PTH treatment was linked to increased PTHrP expression.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreasePTHrP expression
    Study

    micen: not reported in source

    ACH or TDII mice
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The increased expression of PTHrP and down-regulated FGFR3 level may be responsible for the positive effects of PTH on bone phenotype of ACH and TDII mice.
    1 context sentence
    Summary · context
    We here showed that systemic intermittent PTH (1-34) injection can rescue the lethal phenotype of TD type II (TDII) mice and significantly alleviate the retarded skeleton development of ACH mice.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In ACH and TDII mice, PTH treatment was associated with lower FGFR3 levels.

    In plain wordsIn mice with ACH and TDII, PTH treatment was linked to lower FGFR3 levels.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseFGFR3 level
    Study

    micen: not reported in source

    ACH or TDII mice
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The increased expression of PTHrP and down-regulated FGFR3 level may be responsible for the positive effects of PTH on bone phenotype of ACH and TDII mice.
    1 context sentence
    Summary · context
    We here showed that systemic intermittent PTH (1-34) injection can rescue the lethal phenotype of TD type II (TDII) mice and significantly alleviate the retarded skeleton development of ACH mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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