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Study · Not a test of the peptide alone · 2012

4 results

Oxytocin antagonist treatments alter the formation of pair relationships in zebra finches of both sexes.

Pedersen A, Tomaszycki ML

Hormones and behavior24 May 2012Cited by 54 (Europe PMC)

PMID22633910 (opens in a new tab)DOI10.1016/j.yhbeh.2012.05.009 (opens in a new tab)PepBankPUB-22633910
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome

    In male and female zebra finches, an oxytocin antagonist increased the latency to pair compared with vehicle.

    In plain wordsIn zebra finches, a drug that blocks oxytocin made birds slower to form pairs than vehicle did.

    Peptide
    Oxytocin
    Outcome
    IncreaseLatency to pair
    Study

    zebra finchn: not reported in source

    Pair formation test in adult zebra finches with no prior pairing experience
    Comparator
    Vehicle
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    We found that oxytocin antagonists increased the latency to pair and decreased pair formation in both sexes.
    2 context sentences
    Summary · context
    To accomplish this, we systemically administered one of three doses of an oxytocin antagonist (1 μg, 5 μg, or 10 μg) or a vehicle to adult male and female zebra finches (in separate experiments) with no prior pairing experience.
    Summary · context
    Subjects were observed over three days and allowed to choose mates.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome

    In male and female zebra finches, an oxytocin antagonist decreased pair formation compared with vehicle.

    In plain wordsIn zebra finches, a drug that blocks oxytocin led to fewer pairs forming than vehicle did.

    Peptide
    Oxytocin
    Outcome
    DecreasePair formation
    Study

    zebra finchn: not reported in source

    Pair formation test in adult zebra finches with no prior pairing experience
    Comparator
    Vehicle
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    We found that oxytocin antagonists increased the latency to pair and decreased pair formation in both sexes.
    2 context sentences
    Summary · context
    To accomplish this, we systemically administered one of three doses of an oxytocin antagonist (1 μg, 5 μg, or 10 μg) or a vehicle to adult male and female zebra finches (in separate experiments) with no prior pairing experience.
    Summary · context
    Subjects were observed over three days and allowed to choose mates.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome

    In zebra finches, the effects of an oxytocin antagonist on overall pairing behaviors were more pronounced in females than in males.

    In plain wordsIn zebra finches, a drug that blocks oxytocin changed pairing behavior more in females than in males.

    Peptide
    Oxytocin
    Outcome
    MixedSex difference in effect on pairing behaviors
    Study

    zebra finchn: not reported in source

    Pair formation test in adult zebra finches with no prior pairing experience
    Comparator
    Vehicle
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    The effects of these treatments on overall pairing behaviors were more pronounced in females than in males, suggesting sexually differentiated effects on motivation to contact conspecifics.
    2 context sentences
    Summary · context
    To accomplish this, we systemically administered one of three doses of an oxytocin antagonist (1 μg, 5 μg, or 10 μg) or a vehicle to adult male and female zebra finches (in separate experiments) with no prior pairing experience.
    Summary · context
    Subjects were observed over three days and allowed to choose mates.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome

    In male zebra finches, an oxytocin antagonist reduced courtship, measured as directed singing, compared with vehicle.

    In plain wordsIn male zebra finches, a drug that blocks oxytocin reduced courtship singing compared with vehicle.

    Peptide
    Oxytocin
    Outcome
    DecreaseCourtship (directed singing) in males
    Study

    zebra finchn: not reported in source

    Pair formation test in adult zebra finches with no prior pairing experience
    Comparator
    Vehicle
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Treatments also reduced courtship, as measured by directed singing, in males.
    2 context sentences
    Summary · context
    To accomplish this, we systemically administered one of three doses of an oxytocin antagonist (1 μg, 5 μg, or 10 μg) or a vehicle to adult male and female zebra finches (in separate experiments) with no prior pairing experience.
    Summary · context
    Subjects were observed over three days and allowed to choose mates.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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