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Study · Animal study (in vivo) · rabbit · 2013

5 results

PTH [1-34] enhances bone response around titanium implants in a rabbit model of osteoporosis.

Almagro MI, Roman-Blas JA, Bellido M, Castañeda S, Cortez R, Herrero-Beaumont G

Clinical oral implants research25 May 2012Cited by 44 (Europe PMC)

PMID22626278 (opens in a new tab)DOI10.1111/j.1600-0501.2012.02495.x (opens in a new tab)PepBankPUB-22626278
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In osteoporotic rabbits, PTH increased bone-to-implant contact compared with healthy controls.

    In plain wordsIn rabbits with osteoporosis, PTH increased bone contact with implants compared with healthy controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBone-to-implant contact
    Study

    rabbitn: not reported in source

    Ovariectomy and glucocorticoid-induced osteoporosis with titanium implants
    Comparator
    Healthy control rabbits
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 12 weeksAs given in this study (rabbit).

    Source sentences

    Summary
    PTH increased bone-to-implant contact compared with control rabbits or vehicle administration in osteoporotic rabbits (P < 0.005).
    2 context sentences
    Summary · context
    Twenty-eight rabbits had undergone bilateral ovariectomy and further methylprednisolone administration for 4 weeks to induce osteoporosis.
    Summary · context
    At week 8, osteoporotic rabbits started saline vehicle or intermittent PTH administration for 12 weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In osteoporotic rabbits, PTH increased bone-to-implant contact compared with vehicle.

    In plain wordsIn rabbits with osteoporosis, PTH increased bone contact with implants compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBone-to-implant contact
    Study

    rabbitn: not reported in source

    Ovariectomy and glucocorticoid-induced osteoporosis with titanium implants
    Comparator
    Vehicle in osteoporotic rabbits
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 12 weeksAs given in this study (rabbit).

    Source sentences

    Summary
    PTH increased bone-to-implant contact compared with control rabbits or vehicle administration in osteoporotic rabbits (P < 0.005).
    2 context sentences
    Summary · context
    Twenty-eight rabbits had undergone bilateral ovariectomy and further methylprednisolone administration for 4 weeks to induce osteoporosis.
    Summary · context
    At week 8, osteoporotic rabbits started saline vehicle or intermittent PTH administration for 12 weeks.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In osteoporotic rabbits, PTH increased peri-implant BMD compared with vehicle at week 20.

    In plain wordsIn rabbits with osteoporosis, PTH increased bone density around implants compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreasePeri-implant BMD
    Study

    rabbitn: not reported in source

    Ovariectomy and glucocorticoid-induced osteoporosis with titanium implants
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 12 weeksAs given in this study (rabbit).

    Source sentences

    Summary
    PTH-induced new bone formation around external and internal surfaces of titanium implants led to a significant increase of BMD at peri-implant area in osteoporotic rabbits at week 20, when compared with vehicle (P < 0.005).
    2 context sentences
    Summary · context
    Twenty-eight rabbits had undergone bilateral ovariectomy and further methylprednisolone administration for 4 weeks to induce osteoporosis.
    Summary · context
    At week 8, osteoporotic rabbits started saline vehicle or intermittent PTH administration for 12 weeks.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In osteoporotic rabbits, PTH increased BMD in other analysed regions.

    In plain wordsIn rabbits with osteoporosis, PTH increased bone density in other measured regions.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBMD in other analysed regions
    Study

    rabbitn: not reported in source

    Ovariectomy and glucocorticoid-induced osteoporosis with titanium implants
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 12 weeksAs given in this study (rabbit).

    Source sentences

    Summary
    Likewise, PTH increased BMD in other analysed regions.
    2 context sentences
    Summary · context
    Twenty-eight rabbits had undergone bilateral ovariectomy and further methylprednisolone administration for 4 weeks to induce osteoporosis.
    Summary · context
    At week 8, osteoporotic rabbits started saline vehicle or intermittent PTH administration for 12 weeks.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In osteoporotic rabbits, PTH induced new bone formation around the external and internal surfaces of titanium implants.

    In plain wordsIn rabbits with osteoporosis, PTH induced new bone formation around the outer and inner implant surfaces.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseNew bone formation around titanium implants
    Study

    rabbitn: not reported in source

    Ovariectomy and glucocorticoid-induced osteoporosis with titanium implants
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 12 weeksAs given in this study (rabbit).

    Source sentences

    Summary
    PTH-induced new bone formation around external and internal surfaces of titanium implants led to a significant increase of BMD at peri-implant area in osteoporotic rabbits at week 20, when compared with vehicle (P < 0.005).
    2 context sentences
    Summary · context
    Twenty-eight rabbits had undergone bilateral ovariectomy and further methylprednisolone administration for 4 weeks to induce osteoporosis.
    Summary · context
    At week 8, osteoporotic rabbits started saline vehicle or intermittent PTH administration for 12 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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