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Study · Randomized controlled trial · n = 48 · 2012

3 results

Oxytocin selectively moderates negative cognitive appraisals in high trait anxious males.

Alvares GA, Chen NT, Balleine BW, Hickie IB, Guastella AJ

Psychoneuroendocrinology20 May 2012Cited by 56 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In an exploratory analysis in healthy male students, higher trait anxiety went with poorer perceived speech performance in the placebo group, but this link was not found with oxytocin.

    In plain wordsIn healthy young men, an exploratory analysis found that anxious men rated their speech worse on placebo, but not on oxytocin.

    Peptide
    Oxytocin
    Outcome
    DecreaseAssociation of trait anxiety with perceived speech performance
    Study

    n = 48

    Comparator
    Placebo
    Analysis
    Exploratory
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · nasal sprayAs given in this study (human).

    Source sentences

    Summary
    Exploratory analyses revealed that whilst higher trait anxiety was associated with increasingly poorer perceptions of speech performance in the placebo group, this relationship was not found in participants administered oxytocin.
    1 context sentence
    Summary · context
    In a randomized, double-blind, placebo-controlled trial, 48 participants self-administered either an oxytocin or placebo nasal spray and, following a wait period, completed an impromptu speech task.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy male students, oxytocin nasal spray had no overall effect on eye gaze during a social stress task compared with placebo.

    In plain wordsIn healthy young men, oxytocin did not change eye gaze during a speech task compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeEye gaze to audience video during speech task
    Study

    n = 48

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · nasal sprayAs given in this study (human).

    Source sentences

    Summary
    there was no overall effect of oxytocin compared to placebo on either eye gaze or questionnaire measures
    1 context sentence
    Summary · context
    In a randomized, double-blind, placebo-controlled trial, 48 participants self-administered either an oxytocin or placebo nasal spray and, following a wait period, completed an impromptu speech task.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy male students, oxytocin nasal spray had no overall effect on questionnaire measures of negative cognitive appraisal after a speech task compared with placebo.

    In plain wordsIn healthy young men, oxytocin did not change questionnaire scores of negative thoughts about a speech compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeNegative cognitive beliefs about speech performance (questionnaires)
    Study

    n = 48

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · nasal sprayAs given in this study (human).

    Source sentences

    Summary
    there was no overall effect of oxytocin compared to placebo on either eye gaze or questionnaire measures
    1 context sentence
    Summary · context
    In a randomized, double-blind, placebo-controlled trial, 48 participants self-administered either an oxytocin or placebo nasal spray and, following a wait period, completed an impromptu speech task.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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