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Study · Not a test of the peptide alone · 2012

2 results

A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity.

Hilzendeger AM, Morgan DA, Brooks L, Dellsperger D, Liu X, Grobe JL, Rahmouni K, Sigmund CD, Mark AL

American journal of physiology. Heart and circulatory physiology18 May 2012Cited by 92 (Europe PMC)

PMID22610169 (opens in a new tab)PMCIDPMC3404702 (opens in a new tab)DOI10.1152/ajpheart.00974.2011 (opens in a new tab)PepBankPUB-22610169
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

  1. 01AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism

    In rats, intracerebroventricular losartan did not reduce the sympathetic nerve activity responses to the melanocortin agonist MTII, while it inhibited the responses to leptin.

    In plain wordsIn rats, the drug losartan did not reduce the nerve responses to melanotan II, but it did reduce those to leptin.

    Peptide
    Melanotan II
    Outcome
    No significant changeSNA response to MTII after ICV losartan
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    In rats, intracerebroventricular (ICV) administration of losartan (5 μg) selectively inhibited increases in renal and brown adipose tissue (BAT) sympathetic nerve activity (SNA) produced by leptin (10 μg ICV) but did not reduce the SNA responses to corticotrophin-releasing factor (CRF) or the melano…

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

  2. 02AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism

    In mice lacking angiotensin II type-1a receptors, sympathetic nerve responses to MTII were preserved, while responses to leptin were impaired.

    In plain wordsIn mice lacking one angiotensin receptor, nerve responses to melanotan II stayed intact, while those to leptin were weaker.

    Peptide
    Melanotan II
    Outcome
    No significant changeSNA response to MTII in AT1a receptor knockout mice
    Study

    mousen: not reported in source

    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    In mice with deletion of angiotensin II type-1a receptors (AT(1a)R(-/-)), increases in renal and BAT SNA induced by leptin (2 μg ICV) were impaired whereas SNA responses to MTII were preserved.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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