In mice, the MC4R agonist melanotan II did not hyperpolarize the majority of lateral hypothalamic area MC4R-GFP neurons, whereas leptin did.
In plain wordsIn mice, melanotan II did not make most MC4R brain cells in the lateral hypothalamus less active, but leptin did.
- Peptide
- Melanotan II
- Outcome
- No significant changeMembrane response of LHA MC4R-GFP neurons to melanotan II
- Study
mousen: not reported in source
- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
- Studied dose
- Dose not stated
Source sentences
Furthermore, electrophysiological recording demonstrated that leptin, but not the MC4R agonist melanotan II, hyperpolarizes the majority of LHA MC4R-GFP neurons in an ATP- sensitive potassium channel-dependent manner.