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Study · In vitro (cells) · rat · 2013

3 results

Overload training inhibits phagocytosis and ROS generation of peritoneal macrophages: role of IGF-1 and MGF.

Xiao W, Chen P, Wang R, Dong J

European journal of applied physiology17 May 2012Cited by 19 (Europe PMC)

PMID22592456 (opens in a new tab)DOI10.1007/s00421-012-2418-5 (opens in a new tab)PepBankPUB-22592456
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In vitro, MGF peptide impaired phagocytosis of rat peritoneal macrophages in a dose-independent manner.

    In plain wordsIn rat immune cells in a lab dish, MGF peptide weakened the cells' ability to engulf particles.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMacrophage phagocytosis
    Study

    ratn: not reported in source

    rat peritoneal macrophages in vitro
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Unlike IGF-1, MGF peptide impaired the phagocytosis of Mϕs in dose-independent manner.
    1 context sentence
    Summary · context
    In addition, we evaluated the effects of IGF-1 and MGF peptide on phagocytosis and ROS generation of Mϕs in vitro.
  2. 02LabIn vitro (cells)Activity measurement

    In vitro, MGF peptide at 1, 10, 50 and 100 ng/ml significantly inhibited ROS generation by rat peritoneal macrophages.

    In plain wordsIn rat immune cells in a lab dish, MGF peptide at some doses lowered the cells' production of reactive oxygen.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMacrophage ROS generation
    Study

    ratn: not reported in source

    rat peritoneal macrophages in vitro
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    1, 10, 50, 100 ng/mlAs given in this study (rat).

    Source sentences

    Summary
    In addition, MGF peptide of some concentrations (i.e., 1, 10, 50, 100 ng/ml) significantly inhibited the ROS generation of Mϕs.
    1 context sentence
    Summary · context
    In addition, we evaluated the effects of IGF-1 and MGF peptide on phagocytosis and ROS generation of Mϕs in vitro.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats, 11 weeks of overload training increased MGF mRNA levels in peritoneal macrophages compared with sedentary controls.

    In plain wordsIn rats, hard training raised the body's own MGF gene activity in immune cells compared with resting rats.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF mRNA level in macrophages after overload training
    Study

    ratn = 20

    peritoneal macrophages from rats after overload training
    Comparator
    Sedentary control group
    Outcome group
    Immune response · Immune and inflammation

    Measurements

    MGF mRNA level
    92 fold
    overload training vs control

    Source sentences

    Summary
    IGF-1 and MGF mRNA levels in Mϕs from overload training group increased significantly compared with the control group (21-fold and 92-fold, respectively; P < 0.01).
    2 context sentences
    Summary · context
    Rats were randomized to two groups, sedentary control group (n = 10) and overload training group (n = 10).
    Summary · context
    The rats of overload training group were subjected to 11 weeks of experimental training protocol.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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