Pinealon protects the rat offspring from prenatal hyperhomocysteinemia.

Arutjunyan A, Kozina L, Stvolinskiy S, Bulygina Y, Mashkina A, Khavinson V

International journal of clinical and experimental medicine6 Apr 2012Cited by 15 (Europe PMC)

PMID22567179PMCIDPMC3342713PepBankPUB-22567179

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In offspring of methionine-loaded pregnant rats, maternal Pinealon administration improved spatial orientation.
In plain wordsIn rats exposed to prenatal hyperhomocysteinemia, maternal Pinealon treatment improved offspring spatial orientation.
Peptide
Pinealon
Outcome
IncreaseOffspring spatial orientation
Study
ratn: not reported in source
Offspring of pregnant rats with methionine-induced hyperhomocysteinemia
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
the administration of pinealon to pregnant rats loaded with methionine improved their offspring spatial orientation and learning ability
1 context sentence(design, population, supporting numbers)
Summary · context
The offspring of rats with experimental hyperhomocysteinemia caused by alimentary loading with dietary methionine within pregnancy has been studied.
Report a problemFND-2256717901
02AnimalAnimal study (in vivo)Efficacy outcome
In offspring of methionine-loaded pregnant rats, maternal Pinealon administration improved learning ability.
In plain wordsIn rats exposed to prenatal hyperhomocysteinemia, maternal Pinealon treatment improved offspring learning ability.
Peptide
Pinealon
Outcome
IncreaseOffspring learning ability
Study
ratn: not reported in source
Offspring of pregnant rats with methionine-induced hyperhomocysteinemia
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
the administration of pinealon to pregnant rats loaded with methionine improved their offspring spatial orientation and learning ability
1 context sentence(design, population, supporting numbers)
Summary · context
The offspring of rats with experimental hyperhomocysteinemia caused by alimentary loading with dietary methionine within pregnancy has been studied.
Report a problemFND-2256717902
03AnimalAnimal study (in vivo)Mechanism
In offspring of methionine-loaded pregnant rats, maternal Pinealon administration decreased reactive oxygen species accumulation in isolated cerebellar neurons.
In plain wordsIn rats exposed to prenatal hyperhomocysteinemia, maternal Pinealon treatment reduced reactive oxygen species accumulation in isolated offspring cerebellar neurons.
Peptide
Pinealon
Outcome
DecreaseReactive oxygen species accumulation
Study
ratn: not reported in source
Offspring of pregnant rats with methionine-induced hyperhomocysteinemia
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
and decreased both reactive oxygen species accumulation and the number of necrotic cells in the population of the neurons isolated from the cerebellum of the offspring developed under the prenatal hyperhomocysteinemia.
2 context sentences(design, population, supporting numbers)
Summary · context
the administration of pinealon to pregnant rats loaded with methionine
Summary · context
The offspring of rats with experimental hyperhomocysteinemia caused by alimentary loading with dietary methionine within pregnancy has been studied.
Report a problemFND-2256717903
04AnimalAnimal study (in vivo)Efficacy outcome
In offspring of methionine-loaded pregnant rats, maternal Pinealon administration decreased necrotic cells among isolated cerebellar neurons.
In plain wordsIn rats exposed to prenatal hyperhomocysteinemia, maternal Pinealon treatment reduced necrotic cells among isolated offspring cerebellar neurons.
Peptide
Pinealon
Outcome
DecreaseNecrotic cerebellar cells
Study
ratn: not reported in source
Offspring of pregnant rats with methionine-induced hyperhomocysteinemia
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
and decreased both reactive oxygen species accumulation and the number of necrotic cells in the population of the neurons isolated from the cerebellum of the offspring developed under the prenatal hyperhomocysteinemia.
2 context sentences(design, population, supporting numbers)
Summary · context
the administration of pinealon to pregnant rats loaded with methionine
Summary · context
The offspring of rats with experimental hyperhomocysteinemia caused by alimentary loading with dietary methionine within pregnancy has been studied.
Report a problemFND-2256717904

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

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