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Study · Animal study (in vivo) · mouse · 2012

4 results

[The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic selank].

Kozlovskiĭ II, Andreeva LA, Kozlovskaia MM, Nadorova AV, Kolik LG

Eksperimental'naia i klinicheskaia farmakologiia1 Jan 2012Cited by 1 (Europe PMC)

PMID22550852 (opens in a new tab)PepBankPUB-22550852
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In BALB/C mice, selank showed an anxiolytic effect by increasing general locomotor activity in the open field test.

    In plain wordsIn BALB/C mice, selank reduced anxiety-type behavior by raising general movement in the open field test.

    Peptide
    Selank
    Outcome
    IncreaseLocomotor activity in open field (BALB/C)
    Study

    mousen: not reported in source

    BALB/C mice
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    0.25 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Selank (0.25 mg/kg, i.p.) per se exhibited anxiolytic effect in BALB/C mice
    1 context sentence
    Summary · context
    Peculiarities of the anxiolytic effects of selank (heptapeptide analog of taftsin) under reduced activity of opioid system upon acute administration of naloxone have been studied in BALB/C and C57BL/6 inbred mice with high and low levels of anxiety, with passive and active emotional stress reaction…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In C57BL/6 mice, selank had no effect on behavior in the open field test.

    In plain wordsIn C57BL/6 mice, selank had no effect on behavior in the open field test.

    Peptide
    Selank
    Outcome
    No significant changeBehavior in open field (C57BL/6)
    Study

    mousen: not reported in source

    C57BL/6 mice
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    0.25 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Selank (0.25 mg/kg, i.p.) per se exhibited anxiolytic effect in BALB/C mice by increasing the general locomotor activity, with no effects on the behavior of C57BL/6 mice in the OF test.
    1 context sentence
    Summary · context
    Peculiarities of the anxiolytic effects of selank (heptapeptide analog of taftsin) under reduced activity of opioid system upon acute administration of naloxone have been studied in BALB/C and C57BL/6 inbred mice with high and low levels of anxiety, with passive and active emotional stress reaction…
  3. 03AnimalAnimal study (in vivo)Mechanism

    In BALB/C mice, naloxone pretreatment attenuated the sensitivity to selank.

    In plain wordsIn BALB/C mice, blocking the opioid system with naloxone reduced the response to selank.

    Peptide
    Selank
    Outcome
    DecreaseSensitivity to selank after naloxone pretreatment (BALB/C)
    Study

    mousen: not reported in source

    BALB/C mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Pretreatment with naloxone attenuated the sensitivity to selank in BALB/C mice
    1 context sentence
    Summary · context
    Peculiarities of the anxiolytic effects of selank (heptapeptide analog of taftsin) under reduced activity of opioid system upon acute administration of naloxone have been studied in BALB/C and C57BL/6 inbred mice with high and low levels of anxiety, with passive and active emotional stress reaction…
  4. 04AnimalAnimal study (in vivo)Mechanism

    In C57BL/6 mice, naloxone pretreatment increased the response to the anxiolytic effects of selank.

    In plain wordsIn C57BL/6 mice, blocking the opioid system with naloxone increased the response to selank.

    Peptide
    Selank
    Outcome
    IncreaseAnxiolytic response to selank after naloxone pretreatment (C57BL/6)
    Study

    mousen: not reported in source

    C57BL/6 mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    whereas the response to anxiolytic effects of peptide was increased in C57BL/6 mice.
    1 context sentence
    Summary · context
    Peculiarities of the anxiolytic effects of selank (heptapeptide analog of taftsin) under reduced activity of opioid system upon acute administration of naloxone have been studied in BALB/C and C57BL/6 inbred mice with high and low levels of anxiety, with passive and active emotional stress reaction…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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