Vasoactive intestinal peptide enhances striatal plasticity and prevents dopaminergic cell loss in Parkinsonian rats.

Korkmaz O, Ay H, Ulupinar E, Tunçel N

Journal of molecular neuroscience : MN29 Apr 2012Cited by 17 (Europe PMC)

PMID22544516DOI10.1007/s12031-012-9781-xPepBankPUB-22544516

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In 6-OHDA-lesioned rats, VIP significantly increased the number of tyrosine hydroxylase-immunostained neurons.
In plain wordsIn rats with Parkinson-like lesions, VIP increased the number of dopamine-producing nerve cells.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseTyrosine hydroxylase-positive dopaminergic neuron number
Study
ratn: not reported in source
6-OHDA-lesioned Sprague-Dawley rats
Comparator
6-OHDA lesioned rats without VIP
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
25 ng/kg · intraperitoneal · every 2 days for 15 daysAs given in this study (rat).
Source sentences
Summary
VIP significantly increased the number of neurons immunostained with tyrosine hydroxylase
2 context sentences(design, population, supporting numbers)
Summary · context
Adult Sprague-Dawley rats were separated into sham-operated, bilaterally 6-OHDA lesioned and lesioned + i.p. VIP-injected (25 ng/kg) groups.
Summary · context
VIP was first injected 1 h after the intrastriatal 6-OHDA microinjection (every 2 days for 15 days).
Report a problemFND-2254451601
02AnimalAnimal study (in vivo)Efficacy outcome
In 6-OHDA-lesioned rats, VIP significantly increased the density of spines on striatal neurons.
In plain wordsIn rats with Parkinson-like lesions, VIP increased the density of spines on striatal nerve cells.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseStriatal dendritic spine density
Study
ratn: not reported in source
6-OHDA-lesioned Sprague-Dawley rats
Comparator
6-OHDA lesioned rats without VIP
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
25 ng/kg · intraperitoneal · every 2 days for 15 daysAs given in this study (rat).
Source sentences
Summary
the density of spines without altering the branching and the total length of dendrites.
2 context sentences(design, population, supporting numbers)
Summary · context
Adult Sprague-Dawley rats were separated into sham-operated, bilaterally 6-OHDA lesioned and lesioned + i.p. VIP-injected (25 ng/kg) groups.
Summary · context
VIP was first injected 1 h after the intrastriatal 6-OHDA microinjection (every 2 days for 15 days).
Report a problemFND-2254451602
03AnimalAnimal study (in vivo)Efficacy outcome
In 6-OHDA-lesioned rats, VIP did not alter dendritic branching of striatal neurons.
In plain wordsIn rats with Parkinson-like lesions, VIP did not change the branching of striatal nerve cell dendrites.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeStriatal dendritic branching
Study
ratn: not reported in source
6-OHDA-lesioned Sprague-Dawley rats
Comparator
6-OHDA lesioned rats without VIP
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
25 ng/kg · intraperitoneal · every 2 days for 15 daysAs given in this study (rat).
Source sentences
Summary
without altering the branching and the total length of dendrites.
2 context sentences(design, population, supporting numbers)
Summary · context
Adult Sprague-Dawley rats were separated into sham-operated, bilaterally 6-OHDA lesioned and lesioned + i.p. VIP-injected (25 ng/kg) groups.
Summary · context
VIP was first injected 1 h after the intrastriatal 6-OHDA microinjection (every 2 days for 15 days).
Report a problemFND-2254451603
04AnimalAnimal study (in vivo)Efficacy outcome
In 6-OHDA-lesioned rats, VIP did not alter the total length of dendrites of striatal neurons.
In plain wordsIn rats with Parkinson-like lesions, VIP did not change the total length of striatal nerve cell dendrites.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeTotal dendrite length of striatal neurons
Study
ratn: not reported in source
6-OHDA-lesioned Sprague-Dawley rats
Comparator
6-OHDA lesioned rats without VIP
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
25 ng/kg · intraperitoneal · every 2 days for 15 daysAs given in this study (rat).
Source sentences
Summary
without altering the branching and the total length of dendrites.
2 context sentences(design, population, supporting numbers)
Summary · context
Adult Sprague-Dawley rats were separated into sham-operated, bilaterally 6-OHDA lesioned and lesioned + i.p. VIP-injected (25 ng/kg) groups.
Summary · context
VIP was first injected 1 h after the intrastriatal 6-OHDA microinjection (every 2 days for 15 days).
Report a problemFND-2254451604

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

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