Protective effect of GHRP-6 and estrogen supplementation against some cardiometabolic risk factors in ovariectomized rats.

Elbassuoni E, Ragy M, Aziz N

Endocrine regulations1 Apr 2012Cited by 2 (Europe PMC)

PMID22540855DOI10.4149/endo_2012_02_73PepBankPUB-22540855

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, GHRP‑6 did not significantly change body weight gain versus unsupplemented OVX rats.
In plain wordsIn rats with removed ovaries, GHRP‑6 did not significantly change weight gain compared with unsupplemented rats.
Peptide
GHRP-6
Outcome
No significant changeBody weight gain
Study
ratn: not reported in source
ovariectomized adult female rats
Comparator
OVX rats without supplementation
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated · 8 weeksAs given in this study (rat).
Source sentences
Summary
However, GHRP-6 supplemented to OVX rats failed to produce significant change in both the body weight gain and food intake, but reversed the effect of OVX on fasting serum glucose, insulin, insulin resistance, and the assessed lipid fractions.
3 context sentences(design, population, supporting numbers)
Summary · context
The ovariectomy resulted in significant increase of body weight gain, food intake, fasting serum glucose, insulin, insulin resistance, TC, and LDL-C as well as in significant decrease of serum TGs and HDL-C levels.
Summary · context
After 8 weeks, blood samples were collected from the retro-orbital plexus and total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), glucose and insulin in serum were estimated.
Summary · context
Four groups of adult female rats were used: sham operated, OVX, OVX plus estrogen supplemented, and OVX plus GHRP-6 supplemented.
Report a problemFND-2254085501
02AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, GHRP‑6 did not significantly change food intake versus unsupplemented OVX rats.
In plain wordsIn rats with removed ovaries, GHRP‑6 did not significantly change food intake compared with unsupplemented rats.
Peptide
GHRP-6
Outcome
No significant changeFood intake
Study
ratn: not reported in source
ovariectomized adult female rats
Comparator
OVX rats without supplementation
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · 8 weeksAs given in this study (rat).
Source sentences
Summary
However, GHRP-6 supplemented to OVX rats failed to produce significant change in both the body weight gain and food intake, but reversed the effect of OVX on fasting serum glucose, insulin, insulin resistance, and the assessed lipid fractions.
3 context sentences(design, population, supporting numbers)
Summary · context
The ovariectomy resulted in significant increase of body weight gain, food intake, fasting serum glucose, insulin, insulin resistance, TC, and LDL-C as well as in significant decrease of serum TGs and HDL-C levels.
Summary · context
After 8 weeks, blood samples were collected from the retro-orbital plexus and total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), glucose and insulin in serum were estimated.
Summary · context
Four groups of adult female rats were used: sham operated, OVX, OVX plus estrogen supplemented, and OVX plus GHRP-6 supplemented.
Report a problemFND-2254085502
03AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, GHRP‑6 reversed the ovariectomy-related increase in fasting serum glucose.
In plain wordsIn rats with removed ovaries, GHRP‑6 reversed the rise in fasting blood sugar compared with unsupplemented rats.
Peptide
GHRP-6
Outcome
DecreaseFasting serum glucose
Study
ratn: not reported in source
ovariectomized adult female rats
Comparator
OVX rats without supplementation
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated · 8 weeksAs given in this study (rat).
Source sentences
Summary
However, GHRP-6 supplemented to OVX rats failed to produce significant change in both the body weight gain and food intake, but reversed the effect of OVX on fasting serum glucose, insulin, insulin resistance, and the assessed lipid fractions.
3 context sentences(design, population, supporting numbers)
Summary · context
The ovariectomy resulted in significant increase of body weight gain, food intake, fasting serum glucose, insulin, insulin resistance, TC, and LDL-C as well as in significant decrease of serum TGs and HDL-C levels.
Summary · context
After 8 weeks, blood samples were collected from the retro-orbital plexus and total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), glucose and insulin in serum were estimated.
Summary · context
Four groups of adult female rats were used: sham operated, OVX, OVX plus estrogen supplemented, and OVX plus GHRP-6 supplemented.
Report a problemFND-2254085503
04AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, GHRP‑6 reversed the ovariectomy-related increase in serum insulin.
In plain wordsIn rats with removed ovaries, GHRP‑6 reversed the rise in insulin compared with unsupplemented rats.
Peptide
GHRP-6
Outcome
DecreaseSerum insulin
Study
ratn: not reported in source
ovariectomized adult female rats
Comparator
OVX rats without supplementation
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated · 8 weeksAs given in this study (rat).
Source sentences
Summary
However, GHRP-6 supplemented to OVX rats failed to produce significant change in both the body weight gain and food intake, but reversed the effect of OVX on fasting serum glucose, insulin, insulin resistance, and the assessed lipid fractions.
3 context sentences(design, population, supporting numbers)
Summary · context
The ovariectomy resulted in significant increase of body weight gain, food intake, fasting serum glucose, insulin, insulin resistance, TC, and LDL-C as well as in significant decrease of serum TGs and HDL-C levels.
Summary · context
After 8 weeks, blood samples were collected from the retro-orbital plexus and total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), glucose and insulin in serum were estimated.
Summary · context
Four groups of adult female rats were used: sham operated, OVX, OVX plus estrogen supplemented, and OVX plus GHRP-6 supplemented.
Report a problemFND-2254085504
05AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, GHRP‑6 reversed the ovariectomy-related increase in insulin resistance.
In plain wordsIn rats with removed ovaries, GHRP‑6 reversed increased insulin resistance compared with unsupplemented rats.
Peptide
GHRP-6
Outcome
DecreaseInsulin resistance
Study
ratn: not reported in source
ovariectomized adult female rats
Comparator
OVX rats without supplementation
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated · 8 weeksAs given in this study (rat).
Source sentences
Summary
However, GHRP-6 supplemented to OVX rats failed to produce significant change in both the body weight gain and food intake, but reversed the effect of OVX on fasting serum glucose, insulin, insulin resistance, and the assessed lipid fractions.
3 context sentences(design, population, supporting numbers)
Summary · context
The ovariectomy resulted in significant increase of body weight gain, food intake, fasting serum glucose, insulin, insulin resistance, TC, and LDL-C as well as in significant decrease of serum TGs and HDL-C levels.
Summary · context
After 8 weeks, blood samples were collected from the retro-orbital plexus and total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), glucose and insulin in serum were estimated.
Summary · context
Four groups of adult female rats were used: sham operated, OVX, OVX plus estrogen supplemented, and OVX plus GHRP-6 supplemented.
Report a problemFND-2254085505
06AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, GHRP‑6 reversed the ovariectomy-related increase in total cholesterol.
In plain wordsIn rats with removed ovaries, GHRP‑6 reversed increased total cholesterol compared with unsupplemented rats.
Peptide
GHRP-6
Outcome
DecreaseTotal cholesterol
Study
ratn: not reported in source
ovariectomized adult female rats
Comparator
OVX rats without supplementation
Outcome group
Lipids · Metabolic and weight
Studied dose
Dose not stated · 8 weeksAs given in this study (rat).
Source sentences
Summary
However, GHRP-6 supplemented to OVX rats failed to produce significant change in both the body weight gain and food intake, but reversed the effect of OVX on fasting serum glucose, insulin, insulin resistance, and the assessed lipid fractions.
3 context sentences(design, population, supporting numbers)
Summary · context
The ovariectomy resulted in significant increase of body weight gain, food intake, fasting serum glucose, insulin, insulin resistance, TC, and LDL-C as well as in significant decrease of serum TGs and HDL-C levels.
Summary · context
After 8 weeks, blood samples were collected from the retro-orbital plexus and total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), glucose and insulin in serum were estimated.
Summary · context
Four groups of adult female rats were used: sham operated, OVX, OVX plus estrogen supplemented, and OVX plus GHRP-6 supplemented.
Report a problemFND-2254085506
07AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, GHRP‑6 reversed the ovariectomy-related increase in LDL cholesterol.
In plain wordsIn rats with removed ovaries, GHRP‑6 reversed increased LDL cholesterol compared with unsupplemented rats.
Peptide
GHRP-6
Outcome
DecreaseLDL cholesterol
Study
ratn: not reported in source
ovariectomized adult female rats
Comparator
OVX rats without supplementation
Outcome group
Lipids · Metabolic and weight
Studied dose
Dose not stated · 8 weeksAs given in this study (rat).
Source sentences
Summary
However, GHRP-6 supplemented to OVX rats failed to produce significant change in both the body weight gain and food intake, but reversed the effect of OVX on fasting serum glucose, insulin, insulin resistance, and the assessed lipid fractions.
3 context sentences(design, population, supporting numbers)
Summary · context
The ovariectomy resulted in significant increase of body weight gain, food intake, fasting serum glucose, insulin, insulin resistance, TC, and LDL-C as well as in significant decrease of serum TGs and HDL-C levels.
Summary · context
After 8 weeks, blood samples were collected from the retro-orbital plexus and total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), glucose and insulin in serum were estimated.
Summary · context
Four groups of adult female rats were used: sham operated, OVX, OVX plus estrogen supplemented, and OVX plus GHRP-6 supplemented.
Report a problemFND-2254085507
08AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, GHRP‑6 reversed the ovariectomy-related decrease in serum triglycerides.
In plain wordsIn rats with removed ovaries, GHRP‑6 reversed reduced triglycerides compared with unsupplemented rats.
Peptide
GHRP-6
Outcome
IncreaseTriglycerides
Study
ratn: not reported in source
ovariectomized adult female rats
Comparator
OVX rats without supplementation
Outcome group
Lipids · Metabolic and weight
Studied dose
Dose not stated · 8 weeksAs given in this study (rat).
Source sentences
Summary
However, GHRP-6 supplemented to OVX rats failed to produce significant change in both the body weight gain and food intake, but reversed the effect of OVX on fasting serum glucose, insulin, insulin resistance, and the assessed lipid fractions.
3 context sentences(design, population, supporting numbers)
Summary · context
The ovariectomy resulted in significant increase of body weight gain, food intake, fasting serum glucose, insulin, insulin resistance, TC, and LDL-C as well as in significant decrease of serum TGs and HDL-C levels.
Summary · context
After 8 weeks, blood samples were collected from the retro-orbital plexus and total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), glucose and insulin in serum were estimated.
Summary · context
Four groups of adult female rats were used: sham operated, OVX, OVX plus estrogen supplemented, and OVX plus GHRP-6 supplemented.
Report a problemFND-2254085508
09AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, GHRP‑6 reversed the ovariectomy-related decrease in HDL cholesterol.
In plain wordsIn rats with removed ovaries, GHRP‑6 reversed reduced HDL cholesterol compared with unsupplemented rats.
Peptide
GHRP-6
Outcome
IncreaseHDL cholesterol
Study
ratn: not reported in source
ovariectomized adult female rats
Comparator
OVX rats without supplementation
Outcome group
Lipids · Metabolic and weight
Studied dose
Dose not stated · 8 weeksAs given in this study (rat).
Source sentences
Summary
However, GHRP-6 supplemented to OVX rats failed to produce significant change in both the body weight gain and food intake, but reversed the effect of OVX on fasting serum glucose, insulin, insulin resistance, and the assessed lipid fractions.
3 context sentences(design, population, supporting numbers)
Summary · context
The ovariectomy resulted in significant increase of body weight gain, food intake, fasting serum glucose, insulin, insulin resistance, TC, and LDL-C as well as in significant decrease of serum TGs and HDL-C levels.
Summary · context
After 8 weeks, blood samples were collected from the retro-orbital plexus and total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), glucose and insulin in serum were estimated.
Summary · context
Four groups of adult female rats were used: sham operated, OVX, OVX plus estrogen supplemented, and OVX plus GHRP-6 supplemented.
Report a problemFND-2254085509

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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