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Study · Animal study (in vivo) · rat (wistar and 24-month-old females) · 2012

4 results

Oxytocin promotes bone formation during the alveolar healing process in old acyclic female rats.

Colli VC, Okamoto R, Spritzer PM, Dornelles RC

Archives of oral biology22 Apr 2012Cited by 20 (Europe PMC)

PMID22525945 (opens in a new tab)DOI10.1016/j.archoralbio.2012.03.011 (opens in a new tab)PepBankPUB-22525945
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In old acyclic female rats, oxytocin did not change plasma calcium or phosphorus compared with saline.

    In plain wordsIn old female rats, oxytocin did not change blood calcium or phosphorus compared with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changePlasma calcium and phosphorus
    Study

    rat (Wistar, 24-month-old females)n: not reported in source

    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    45 μg/rat, two injections 12 h apart · intraperitonealAs given in this study (rat (Wistar, 24-month-old females)).

    Source sentences

    Summary
    Calcium and phosphorus plasma concentrations did not differ between the groups.
    1 context sentence
    Summary · context
    Females Wistar rats (24-month-old) in permanent diestrus phase, received two ip (12h apart) injections of saline (NaCl 0.15M - control group) or OT (45μg/rat - treated group).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In old acyclic female rats, oxytocin raised plasma bone formation markers alkaline phosphatase and osteocalcin compared with saline.

    In plain wordsIn old female rats, oxytocin raised blood markers of bone formation compared with saline.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma ALP and osteocalcin (bone formation markers)
    Study

    rat (Wistar, 24-month-old females)n: not reported in source

    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    45 μg/rat, two injections 12 h apart · intraperitonealAs given in this study (rat (Wistar, 24-month-old females)).

    Source sentences

    Summary
    The plasma biochemical bone formations markers, alkaline phosphatase (ALP) and osteocalcin were significantly higher in the treated group.
    1 context sentence
    Summary · context
    Females Wistar rats (24-month-old) in permanent diestrus phase, received two ip (12h apart) injections of saline (NaCl 0.15M - control group) or OT (45μg/rat - treated group).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In old acyclic female rats, oxytocin-treated animals had the highest mean post-extraction bone formation in the alveolar socket.

    In plain wordsIn old female rats, oxytocin-treated animals formed more new bone in the tooth socket than saline-treated animals.

    Peptide
    Oxytocin
    Outcome
    IncreasePost-extraction bone formation (histomorphometry)
    Study

    rat (Wistar, 24-month-old females)n: not reported in source

    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    45 μg/rat, two injections 12 h apart · intraperitonealAs given in this study (rat (Wistar, 24-month-old females)).

    Source sentences

    Summary
    Histomorphometric analyses confirmed bone formation as the treated group presented the highest mean value of post-extraction bone formation.
    1 context sentence
    Summary · context
    Females Wistar rats (24-month-old) in permanent diestrus phase, received two ip (12h apart) injections of saline (NaCl 0.15M - control group) or OT (45μg/rat - treated group).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In old acyclic female rats, oxytocin significantly reduced tartrate-resistant acid phosphatase, an anti-resorptive effect.

    In plain wordsIn old female rats, oxytocin lowered a marker of bone breakdown compared with saline.

    Peptide
    Oxytocin
    Outcome
    DecreaseTRAP (bone resorption marker)
    Study

    rat (Wistar, 24-month-old females)n: not reported in source

    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    45 μg/rat, two injections 12 h apart · intraperitonealAs given in this study (rat (Wistar, 24-month-old females)).

    Source sentences

    Summary
    Tartrate-resistant acid phosphatase (TRAP) was significantly reduced in the treated group indicating an anti-resorptive effect of OT.
    1 context sentence
    Summary · context
    Females Wistar rats (24-month-old) in permanent diestrus phase, received two ip (12h apart) injections of saline (NaCl 0.15M - control group) or OT (45μg/rat - treated group).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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