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Study · Not a test of the peptide alone · 2012

4 results

Combined nuclear magnetic resonance spectroscopy and molecular dynamics study of growth hormone releasing hexapeptide GHRP-6 and a cyclic analogue.

Fernández-Oliva M, Santana H, Suardíaz R, Gavín JA, Pérez CS

Magnetic resonance in chemistry : MRC12 Apr 2012Cited by 3 (Europe PMC)

PMID22499151 (opens in a new tab)DOI10.1002/mrc.3805 (opens in a new tab)PepBankPUB-22499151
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01LabNot a test of GHRP-6 aloneIn vitro (cell-free)Mechanism

    In NMR experiments, GHRP‑6 chemical shifts differed from random coil values.

    In plain wordsIn lab tests, GHRP‑6 showed chemical shifts that differed from random coil values.

    Peptide
    GHRP-6
    Outcome
    Not applicableResonance assignment
    Study

    n: not reported in source

    GHRP-6 NMR spectra
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Complete resonance assignment of GHRP-6 NMR spectra in both open and cyclic forms are reported, showing some differences to random coil chemical shifts.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 02LabNot a test of GHRP-6 aloneIn vitro (cell-free)Mechanism

    GHRP‑6 ROESY spectra showed proximity among aromatic side-chains and between DPhe5 and Lys6 sidechains.

    In plain wordsIn lab tests, GHRP‑6 spectra showed nearby aromatic side-chains and nearby DPhe5 and Lys6 sidechains.

    Peptide
    GHRP-6
    Outcome
    Not applicableSide-chain spatial proximity
    Study

    n: not reported in source

    GHRP-6 ROESY spectra
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Connectivities observed in the ROESY spectra indicate spatial proximity between the aromatic residues side-chains in both molecules, as well as between residues DPhe5 and Lys6 sidechains.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 03Computer modelNot a test of GHRP-6 aloneIn silicoMechanism

    The GHRP‑6 ensemble contained 10 structures with RMSD values indicative of nonrandom structures.

    In plain wordsIn computer models, GHRP‑6 structures showed patterns that differed from random structures.

    Peptide
    GHRP-6
    Outcome
    Not applicableNonrandom structural ensemble
    Study

    n: not reported in source

    GHRP-6 structural ensemble
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    An ensemble of 10 structures was generated for each one of the molecules, showing RMSD values indicative of nonrandom structures.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  4. 04Computer modelNot a test of GHRP-6 aloneIn silicoMechanism

    Molecular dynamics analysis of GHRP‑6 showed a nonrandom structure with a well preserved backbone.

    In plain wordsIn computer models, GHRP‑6 maintained a nonrandom structure with a preserved backbone.

    Peptide
    GHRP-6
    Outcome
    Not applicableBackbone conformation
    Study

    n: not reported in source

    GHRP-6 molecular dynamics trajectories
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Conformational analysis performed on the trajectories showed a nonrandom structure with a well preserved backbone.
    1 context sentence
    Summary · context
    Molecular Dynamics simulations, both with and without explicit solvent, were carried out for GHRP-6 and its cyclic analogue.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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