In GH-deficient lit/lit mice, 10 mcg of GHRP‑2 raised serum GH to 9.3 ng/ml versus 1.04 ng/ml in controls.
In plain wordsIn mice lacking a working GHRH receptor, GHRP‑2 still raised growth hormone compared with controls.
- Peptide
- GHRP-2
- Outcome
- IncreaseSerum GH response to GHRP-2
- Study
mousen: not reported in source
GH-deficient lit/lit mice (GHRH receptor mutation)- Comparator
- Controls
- Outcome group
- Growth hormone and IGF-1 · Endocrine and hormones
- Studied dose
- 10 mcgAs given in this study (mouse).
Measurements
- Serum GH
- 9.3 ng/ml
- lit/lit mice after GHRP-2
- Serum GH
- 1.04 ng/ml
- controls
Source sentences
After the administration of 10 mcg of growth hormone-releasing P-2 to lit/lit mice, a growth hormone release of 9.3±1.5 ng/ml was observed compared with 1.04±1.15 ng/ml in controls (p<0.001).
1 context sentence(design, population, supporting numbers)
The responses of serum growth hormone to acutely injected growth hormone-releasing P-2 in lit/lit mice, which represent a model of GH deficiency arising from mutated growth hormone-releasing hormone-receptors, were compared to those observed in the heterozygous (lit/+) littermates and wild-type (+/+) C57BL/6J mice.