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Study · Randomized controlled trial · n = 57 · 2012

2 results

Salivary levels of oxytocin remain elevated for more than two hours after intranasal oxytocin administration.

Huffmeijer R, Alink LR, Tops M, Grewen KM, Light KC, Bakermans-Kranenburg MJ, Ijzendoorn MH

Neuro endocrinology letters1 Jan 2012Cited by 34 (Europe PMC)

PMID22467107 (opens in a new tab)PepBankPUB-22467107
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialPharmacokinetics

    In 57 women, salivary oxytocin increased markedly after intranasal oxytocin compared with placebo.

    In plain wordsIn 57 women, oxytocin in saliva rose markedly after the spray, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseSalivary oxytocin after administration
    Study

    n = 57

    Comparator
    Placebo
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    16 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    markedly increased only after oxytocin administration, and were still elevated after 2¼ h.
    1 context sentence
    Summary · context
    Oxytocin levels were measured in saliva samples collected from 57 female participants right before (T0), approximately 1¼ h (T1), and approximately 2¼ h (T2) after intranasal administration of 16 IU of oxytocin or a placebo, using a double-blind, within-subjects design.
  2. 02HumanRandomized controlled trialPharmacokinetics

    In 57 women, salivary oxytocin was still elevated about 2 hours after intranasal oxytocin compared with placebo.

    In plain wordsIn 57 women, oxytocin in saliva was still raised over two hours after the spray, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseSalivary oxytocin about 2 h after administration
    Study

    n = 57

    Comparator
    Placebo
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    16 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    and were still elevated after 2¼ h.
    1 context sentence
    Summary · context
    Oxytocin levels were measured in saliva samples collected from 57 female participants right before (T0), approximately 1¼ h (T1), and approximately 2¼ h (T2) after intranasal administration of 16 IU of oxytocin or a placebo, using a double-blind, within-subjects design.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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