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Study · In vitro (cells) · sheep · 2012

3 results

IGF-2R-mediated signaling results in hypertrophy of cultured cardiomyocytes from fetal sheep.

Wang KC, Brooks DA, Botting KJ, Morrison JL

Biology of reproduction22 Jun 2012Cited by 27 (Europe PMC)

PMID22441800 (opens in a new tab)DOI10.1095/biolreprod.112.100388 (opens in a new tab)PepBankPUB-22441800
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cultured fetal sheep cardiomyocytes, IGF-1R activation with LONG R3 IGF-1 resulted in ERK signaling.

    In plain wordsIn sheep heart cells grown in the lab, LONG R3 IGF-1 activated ERK signaling.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseERK signaling after IGF-1R activation
    Study

    sheepn: not reported in source

    cultured fetal sheep cardiomyocytes
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IGF-1R and IGF-2R activation each resulted in ERK signaling, but IGF-2R activation alone induced CaMKII signaling, resulting in hypertrophy of cardiomyocytes in the late gestation sheep fetus.
    2 context sentences
    Summary · context
    Cultured cardiomyocytes were treated with either LONG R(3)IGF-1, an IGF-1R agonist
    Summary · context
    Fetal sheep hearts (125 ± 0.4 days gestation) were dissected, and the cardiomyocytes isolated from the left and right ventricles for culturing.
  2. 02LabIn vitro (cells)Mechanism

    In cultured fetal sheep cardiomyocytes, IGF-1R activation with LONG R3 IGF-1 did not induce CaMKII signaling, which IGF-2R activation alone induced.

    In plain wordsIn sheep heart cells grown in the lab, LONG R3 IGF-1 did not trigger CaMKII signaling.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeCaMKII signaling after IGF-1R activation
    Study

    sheepn: not reported in source

    cultured fetal sheep cardiomyocytes
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IGF-1R and IGF-2R activation each resulted in ERK signaling, but IGF-2R activation alone induced CaMKII signaling, resulting in hypertrophy of cardiomyocytes in the late gestation sheep fetus.
    2 context sentences
    Summary · context
    Cultured cardiomyocytes were treated with either LONG R(3)IGF-1, an IGF-1R agonist
    Summary · context
    Fetal sheep hearts (125 ± 0.4 days gestation) were dissected, and the cardiomyocytes isolated from the left and right ventricles for culturing.
  3. 03LabIn vitro (cells)Efficacy outcome

    In cultured fetal sheep cardiomyocytes, IGF-1R activation with LONG R3 IGF-1 did not cause hypertrophy, which IGF-2R activation alone caused.

    In plain wordsIn sheep heart cells grown in the lab, LONG R3 IGF-1 did not cause the cells to enlarge.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeCardiomyocyte hypertrophy after IGF-1R activation
    Study

    sheepn: not reported in source

    cultured fetal sheep cardiomyocytes
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IGF-1R and IGF-2R activation each resulted in ERK signaling, but IGF-2R activation alone induced CaMKII signaling, resulting in hypertrophy of cardiomyocytes in the late gestation sheep fetus.
    2 context sentences
    Summary · context
    Cultured cardiomyocytes were treated with either LONG R(3)IGF-1, an IGF-1R agonist
    Summary · context
    Fetal sheep hearts (125 ± 0.4 days gestation) were dissected, and the cardiomyocytes isolated from the left and right ventricles for culturing.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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