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Study · Animal study (in vivo) · rat · 2001

6 results

Delta-sleep inducing peptide (DSIP) and ACTH (4-10) analogue influence fos-induction in the limbic structures of the rat brain under emotional stress.

Sudakov KV, Umriukhin PE, Koplik EV, Anokhin KV

Stress (Amsterdam, Netherlands)1 Jun 2001Cited by 9 (Europe PMC)

PMID22432135 (opens in a new tab)DOI10.3109/10253890109115728 (opens in a new tab)PepBankPUB-22432135
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats resistant to emotional stress, intraperitoneal DSIP at 30 ug/kg increased basal Fos-immunoreactive cell number in the pPVN and lateral septum.

    In plain wordsIn stress-resistant rats, DSIP raised the number of Fos-positive cells in two brain areas under resting conditions.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseBasal Fos-IR cell number in pPVN and lateral septum, resistant rats
    Study

    ratn: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    30 ug/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Intraperitoneal DSIP injection (30 μg/kg) increased basal Fos-IR cell number in the pPVN and lateral septum in resistant rats, with no effects in predisposed rats.
    1 context sentence
    Summary · context
    The effects of the ACTH (4-10) analogue, ACTH (4-7)-Pro-Gly-Pro, and delta-sleep inducing peptide (DSIP) on the induction of Fos immunoreactivity in the hypothalamic parvocellular paraventricular nucleus (pPVN) and limbic brain regions were studied in Wistar rats with high (resistant) or low (predis…
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats predisposed to emotional stress, intraperitoneal DSIP at 30 ug/kg had no effect on basal Fos-immunoreactive cell number.

    In plain wordsIn stress-predisposed rats, DSIP did not change Fos-positive cell numbers under resting conditions.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeBasal Fos-IR cell number, predisposed rats
    Study

    ratn: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    30 ug/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Intraperitoneal DSIP injection (30 μg/kg) increased basal Fos-IR cell number in the pPVN and lateral septum in resistant rats, with no effects in predisposed rats.
    1 context sentence
    Summary · context
    The effects of the ACTH (4-10) analogue, ACTH (4-7)-Pro-Gly-Pro, and delta-sleep inducing peptide (DSIP) on the induction of Fos immunoreactivity in the hypothalamic parvocellular paraventricular nucleus (pPVN) and limbic brain regions were studied in Wistar rats with high (resistant) or low (predis…
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats exposed to emotional stress, intraperitoneal DSIP reduced the stress-induced increases in Fos-immunoreactive cell number, particularly in predisposed rats.

    In plain wordsIn rats under stress, DSIP reduced the rise in Fos-positive brain cells, most in stress-predisposed rats.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseStress-induced increase in Fos-IR cell number
    Study

    ratn: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Intraperitoneal DSIP injection reduced the increases in Fos-IR cell number after emotional stress, particularly in predisposed rats.
    1 context sentence
    Summary · context
    The effects of the ACTH (4-10) analogue, ACTH (4-7)-Pro-Gly-Pro, and delta-sleep inducing peptide (DSIP) on the induction of Fos immunoreactivity in the hypothalamic parvocellular paraventricular nucleus (pPVN) and limbic brain regions were studied in Wistar rats with high (resistant) or low (predis…
  4. 04AnimalAnimal study (in vivo)Mechanism

    In stress-predisposed rats, DSIP decreased the number of Fos-immunoreactive cells in the pPVN and the medial and lateral septum.

    In plain wordsIn stress-predisposed rats, DSIP lowered the number of Fos-positive cells in three stress-related brain areas.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseStress-induced Fos-IR cells in pPVN and medial and lateral septum, predisposed rats
    Study

    ratn: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In predisposed rats DSIP decreased the number of Fos-IR cells in the pPVN and the medial and lateral septum, with no change in the basolateral amygdala.
    1 context sentence
    Summary · context
    The effects of the ACTH (4-10) analogue, ACTH (4-7)-Pro-Gly-Pro, and delta-sleep inducing peptide (DSIP) on the induction of Fos immunoreactivity in the hypothalamic parvocellular paraventricular nucleus (pPVN) and limbic brain regions were studied in Wistar rats with high (resistant) or low (predis…
  5. 05AnimalAnimal study (in vivo)Mechanism

    In stress-predisposed rats, DSIP produced no change in the number of Fos-immunoreactive cells in the basolateral amygdala.

    In plain wordsIn stress-predisposed rats, DSIP did not change Fos-positive cell numbers in the basolateral amygdala.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeStress-induced Fos-IR cells in basolateral amygdala, predisposed rats
    Study

    ratn: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    with no change in the basolateral amygdala.
    1 context sentence
    Summary · context
    The effects of the ACTH (4-10) analogue, ACTH (4-7)-Pro-Gly-Pro, and delta-sleep inducing peptide (DSIP) on the induction of Fos immunoreactivity in the hypothalamic parvocellular paraventricular nucleus (pPVN) and limbic brain regions were studied in Wistar rats with high (resistant) or low (predis…
  6. 06AnimalAnimal study (in vivo)Mechanism

    In stress-resistant rats, DSIP decreased stress-induced Fos expression only in the lateral septum.

    In plain wordsIn stress-resistant rats, DSIP lowered Fos expression in the lateral septum only.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseStress-induced Fos expression, resistant rats
    Study

    ratn: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In resistant rats, DSIP decreased Fos expression only in the lateral septum.
    1 context sentence
    Summary · context
    The effects of the ACTH (4-10) analogue, ACTH (4-7)-Pro-Gly-Pro, and delta-sleep inducing peptide (DSIP) on the induction of Fos immunoreactivity in the hypothalamic parvocellular paraventricular nucleus (pPVN) and limbic brain regions were studied in Wistar rats with high (resistant) or low (predis…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 12:40 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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