Oxytocin prolongs the gastric emptying time in patients with diabetes mellitus and gastroparesis, but does not affect satiety or volume intake in patients with functional dyspepsia.

Borg J, Ohlsson B

BMC research notes16 Mar 2012Cited by 8 (Europe PMC)

PMID22420866PMCIDPMC3325871DOI10.1186/1756-0500-5-148PepBankPUB-22420866

Summary

BackgroundOxytocin is released in response to a fatty meal. Blockage of the oxytocin receptor led to slower gastric emptying whereas stimulation resulted in less satiety in healthy volunteers. Patients with diabetes mellitus and gastroparesis lack oxytocin elevation, and dyspepsia is partly caused by reduced fundus accommodation causing early satiety and related symptoms. The aim of this study was thus to examine the effect of oxytocin on gastric emptying, satiety and volume intake in patients with gastrointestinal pathology.ResultsGastric emptying scintigraphy was performed twice in 12 patients with diabetic gastroparesis, once with oxytocin and once with saline as intravenous infusions. The patients scored their sensation of satiety using a visual analogue scale (VAS). The gastric emptying in patients with gastroparesis was prolonged during oxytocin infusion (p = 0.034) without affecting satiety. A slow satiety drinking test was performed in 14 patients with functional dyspepsia. The patients scored their satiety every five minutes until maximal satiety was reached, and the total volume was determined. The VAS was also completed 30 minutes afterwards. The test was performed twice, once with oxytocin and once with saline as intravenous infusions. There was no difference in satiety scores or volume of nutrient intake between saline and oxytocin infusions, either before, during or after the meal.ConclusionsOxytocin prolongs gastric emptying in patients with diabetes mellitus and gastroparesis, but has no effect on volume of nutrient intake or satiety and other related symptoms in patients with functional dyspepsia.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanRandomized controlled trialEfficacy outcome
In 14 patients with functional dyspepsia, intravenous oxytocin gave no difference in satiety scores compared with saline.
In plain wordsIn 14 people with functional dyspepsia, oxytocin did not change fullness scores compared with saline.
Peptide
Oxytocin
Outcome
No significant changeSatiety scores in functional dyspepsia
Study
n = 14
Comparator
Saline
Outcome group
Appetite and food intake · Gastrointestinal
Studied dose
Dose not stated · intravenous infusionAs given in this study (human).
Source sentences
Summary
There was no difference in satiety scores or volume of nutrient intake between saline and oxytocin infusions
1 context sentence(design, population, supporting numbers)
Summary · context
A slow satiety drinking test was performed in 14 patients with functional dyspepsia.
Show in the study text Report a problemFND-2242086603
02HumanRandomized controlled trialEfficacy outcome
In 14 patients with functional dyspepsia, intravenous oxytocin gave no difference in the volume of nutrient intake compared with saline.
In plain wordsIn 14 people with functional dyspepsia, oxytocin did not change how much they could drink compared with saline.
Peptide
Oxytocin
Outcome
No significant changeVolume of nutrient intake in functional dyspepsia
Study
n = 14
Comparator
Saline
Outcome group
Appetite and food intake · Gastrointestinal
Studied dose
Dose not stated · intravenous infusionAs given in this study (human).
Source sentences
Summary
There was no difference in satiety scores or volume of nutrient intake between saline and oxytocin infusions
1 context sentence(design, population, supporting numbers)
Summary · context
A slow satiety drinking test was performed in 14 patients with functional dyspepsia.
Show in the study text Report a problemFND-2242086604
03HumanRandomized controlled trialEfficacy outcome
In 12 patients with diabetic gastroparesis, intravenous oxytocin prolonged gastric emptying compared with saline (p = 0.034).
In plain wordsIn 12 people with diabetic gastroparesis, oxytocin slowed stomach emptying compared with saline.
Peptide
Oxytocin
Outcome
IncreaseGastric emptying time in diabetic gastroparesis
Study
n = 12
Comparator
Saline
Outcome group
Gastrointestinal motility · Gastrointestinal
Studied dose
Dose not stated · intravenous infusionAs given in this study (human).
Source sentences
Summary
The gastric emptying in patients with gastroparesis was prolonged during oxytocin infusion (p = 0.034)
1 context sentence(design, population, supporting numbers)
Summary · context
Gastric emptying scintigraphy was performed twice in 12 patients with diabetic gastroparesis, once with oxytocin and once with saline as intravenous infusions.
Show in the study text Report a problemFND-2242086601
04HumanRandomized controlled trialEfficacy outcome
In 12 patients with diabetic gastroparesis, intravenous oxytocin did not change satiety compared with saline.
In plain wordsIn 12 people with diabetic gastroparesis, oxytocin did not change the feeling of fullness compared with saline.
Peptide
Oxytocin
Outcome
No significant changeSatiety (VAS) in diabetic gastroparesis
Study
n = 12
Comparator
Saline
Outcome group
Appetite and food intake · Gastrointestinal
Studied dose
Dose not stated · intravenous infusionAs given in this study (human).
Source sentences
Summary
The gastric emptying in patients with gastroparesis was prolonged during oxytocin infusion (p = 0.034) without affecting satiety.
1 context sentence(design, population, supporting numbers)
Summary · context
The patients scored their sensation of satiety using a visual analogue scale (VAS).
Show in the study text Report a problemFND-2242086602

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 01:30 UTC
Study results updated
Version 1
9 Oct 2026, 02:49 UTC
First added · source update from Europe PMC

Subjects

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