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Study · Animal study (in vivo) · rat · 2012

1 result

Strategies to defeat ketamine-induced neonatal brain injury.

Turner CP, Gutierrez S, Liu C, Miller L, Chou J, Finucane B, Carnes A, Kim J, Shing E, Haddad T, Phillips A

Neuroscience23 Feb 2012Cited by 29 (Europe PMC)

PMID22406413 (opens in a new tab)PMCIDPMC3358446 (opens in a new tab)DOI10.1016/j.neuroscience.2012.02.015 (opens in a new tab)PepBankPUB-22406413
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal rats, NAP given before ketamine dose-dependently reversed brain injury.

    In plain wordsIn neonatal rats, NAP before ketamine reduced brain injury compared with ketamine alone, with a dose-dependent response.

    Peptide
    Davunetide
    Outcome
    DecreaseKetamine-induced brain injury
    Study

    ratn: not reported in source

    ketamine-induced neonatal brain injury
    Comparator
    Ketamine without NAP
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thus, we injected P7 animals with the ADNP peptide fragment NAPVSIPQ (NAP) 15 min before ketamine administration and found we could dose-dependently reverse the injury.
    3 context sentences
    Summary · context
    Postnatal day 7 (P7) rats were injected with vehicle (sterile PBS) or the NMDAR antagonist ketamine (20 mg/kg).
    Summary · context
    After 8 h, we prepared brains for immunohistochemical detection of the pro-apoptotic enzyme activated caspase-3 (AC3).
    Summary · context
    Focusing on the somatosensory cortex, AC3-positive cells were then counted in a non-biased stereological manner.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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