Skip to content

Study · In vitro (cells) · 2012

8 results

Larazotide acetate promotes tight junction assembly in epithelial cells.

Gopalakrishnan S, Tripathi A, Tamiz AP, Alkan SS, Pandey NB

Peptides28 Feb 2012Cited by 59 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In MDCK cells, larazotide promoted tight junction assembly in a calcium switch assay.

    In plain wordsIn cells, larazotide promoted tight junction assembly in a calcium switch assay.

    Peptide
    Larazotide
    Outcome
    IncreaseTight junction assembly
    Study

    n: not reported in source

    MDCK cells
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In MDCK cells, larazotide acetate promoted TJ assembly in a calcium switch assay.
  2. 02LabIn vitro (cells)Mechanism

    In epithelial cells, larazotide promoted actin rearrangement.

    In plain wordsIn cells, larazotide promoted actin rearrangement.

    Peptide
    Larazotide
    Outcome
    IncreaseActin rearrangement
    Study

    n: not reported in source

    MDCK cells
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Larazotide acetate also promoted actin rearrangement, and junctional distribution of zonula occludens-1 (ZO-1), occludin, claudins, and E-cadherin.
  3. 03LabIn vitro (cells)Mechanism

    In epithelial cells, larazotide promoted junctional distribution of ZO-1.

    In plain wordsIn cells, larazotide promoted ZO-1 distribution at cell junctions.

    Peptide
    Larazotide
    Outcome
    IncreaseZO-1 junctional distribution
    Study

    n: not reported in source

    MDCK cells
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Larazotide acetate also promoted actin rearrangement, and junctional distribution of zonula occludens-1 (ZO-1), occludin, claudins, and E-cadherin.
  4. 04LabIn vitro (cells)Mechanism

    In epithelial cells, larazotide promoted junctional distribution of occludin.

    In plain wordsIn cells, larazotide promoted occludin distribution at cell junctions.

    Peptide
    Larazotide
    Outcome
    IncreaseOccludin junctional distribution
    Study

    n: not reported in source

    MDCK cells
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Larazotide acetate also promoted actin rearrangement, and junctional distribution of zonula occludens-1 (ZO-1), occludin, claudins, and E-cadherin.
  5. 05LabIn vitro (cells)Mechanism

    In epithelial cells, larazotide promoted junctional distribution of claudins.

    In plain wordsIn cells, larazotide promoted claudin distribution at cell junctions.

    Peptide
    Larazotide
    Outcome
    IncreaseClaudin junctional distribution
    Study

    n: not reported in source

    MDCK cells
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Larazotide acetate also promoted actin rearrangement, and junctional distribution of zonula occludens-1 (ZO-1), occludin, claudins, and E-cadherin.
  6. 06LabIn vitro (cells)Mechanism

    In epithelial cells, larazotide promoted junctional distribution of E-cadherin.

    In plain wordsIn cells, larazotide promoted E-cadherin distribution at cell junctions.

    Peptide
    Larazotide
    Outcome
    IncreaseE-cadherin junctional distribution
    Study

    n: not reported in source

    MDCK cells
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Larazotide acetate also promoted actin rearrangement, and junctional distribution of zonula occludens-1 (ZO-1), occludin, claudins, and E-cadherin.
  7. 07LabIn vitro (cells)Mechanism

    In leaky Caco-2 cells, larazotide promoted tight junction maturation.

    In plain wordsIn cells, larazotide promoted tight junction maturation.

    Peptide
    Larazotide
    Outcome
    IncreaseTight junction maturation
    Study

    n: not reported in source

    Leaky Caco-2 cells
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Larazotide acetate promoted TJ maturation and decreased paracellular permeability in "leaky" Caco-2 cells.
  8. 08LabIn vitro (cells)Mechanism

    In leaky Caco-2 cells, larazotide decreased paracellular permeability.

    In plain wordsIn cells, larazotide decreased passage between cells.

    Peptide
    Larazotide
    Outcome
    DecreaseParacellular permeability
    Study

    n: not reported in source

    Leaky Caco-2 cells
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Larazotide acetate promoted TJ maturation and decreased paracellular permeability in "leaky" Caco-2 cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.