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Study · Ex vivo tissue · 2011

5 results

[Peptidergic modulation of the hippocampus synaptic activity].

Skrebitskiĭ VG, Kondratenko RV, Povarov IS, Dereviagin VI

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova1 Nov 2011

PMID22390072 (opens in a new tab)PepBankPUB-22390072
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In hippocampal CA1 pyramidal cells, bath-applied selank increased the frequency of spike-dependent spontaneous inhibitory postsynaptic currents.

    In plain wordsIn lab recordings of brain cells, selank raised the rate of spike-dependent inhibitory signals.

    Peptide
    Selank
    Outcome
    IncreaseFrequency of spike-dependent spontaneous inhibitory postsynaptic currents
    Study

    n: not reported in source

    Hippocampal CA1 pyramidal cells, patch-clamp
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2 microM · bath applicationAs given in this study.

    Source sentences

    Summary
    Bath application of Noopept (1 microM) or Selank (2 microM) significantly increased the frequency of spike-dependent spontaneous m1PSCs, whereas spike-independent mlPSCs remained unchanged.
    1 context sentence
    Summary · context
    Effects of two newly synthesized nootropic and anxiolytic dipeptides: Noopept and Selank on inhibitory synaptic transmission in hippocampal CA1 pyramidal cells were investigated using patch-clamp technique in whole-cell configuration.
  2. 02LabEx vivo tissueMechanism

    In hippocampal CA1 pyramidal cells, bath-applied selank left spike-independent inhibitory postsynaptic currents unchanged.

    In plain wordsIn lab recordings of brain cells, selank did not change the rate of spike-independent inhibitory signals.

    Peptide
    Selank
    Outcome
    No significant changeFrequency of spike-independent inhibitory postsynaptic currents
    Study

    n: not reported in source

    Hippocampal CA1 pyramidal cells, patch-clamp
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2 microM · bath applicationAs given in this study.

    Source sentences

    Summary
    Bath application of Noopept (1 microM) or Selank (2 microM) significantly increased the frequency of spike-dependent spontaneous m1PSCs, whereas spike-independent mlPSCs remained unchanged.
    1 context sentence
    Summary · context
    Effects of two newly synthesized nootropic and anxiolytic dipeptides: Noopept and Selank on inhibitory synaptic transmission in hippocampal CA1 pyramidal cells were investigated using patch-clamp technique in whole-cell configuration.
  3. 03LabEx vivo tissueActivity measurement

    In hippocampal CA1 pyramidal cells, Noopept increased the frequency of spike-dependent spontaneous inhibitory postsynaptic currents.

    In plain wordsIn lab tests, Noopept increased the frequency of spike-dependent inhibitory currents in hippocampal cells.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseSpike-dependent spontaneous inhibitory postsynaptic current frequency
    Study

    n: not reported in source

    Hippocampal CA1 pyramidal cells and stratum radiatum inhibitory interneurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 microM · bath applicationAs given in this study.

    Source sentences

    Summary
    Bath application of Noopept (1 microM) or Selank (2 microM) significantly increased the frequency of spike-dependent spontaneous m1PSCs, whereas spike-independent mlPSCs remained unchanged.
    1 context sentence
    Summary · context
    Effects of two newly synthesized nootropic and anxiolytic dipeptides: Noopept and Selank on inhibitory synaptic transmission in hippocampal CA1 pyramidal cells were investigated using patch-clamp technique in whole-cell configuration.
  4. 04LabEx vivo tissueActivity measurement

    In hippocampal CA1 pyramidal cells, Noopept did not change spike-independent inhibitory postsynaptic currents.

    In plain wordsIn lab tests, Noopept did not change spike-independent inhibitory currents in hippocampal cells.

    Peptide
    Noopept (omberacetam)
    Outcome
    No significant changeSpike-independent inhibitory postsynaptic currents
    Study

    n: not reported in source

    Hippocampal CA1 pyramidal cells and stratum radiatum inhibitory interneurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 microM · bath applicationAs given in this study.

    Source sentences

    Summary
    Bath application of Noopept (1 microM) or Selank (2 microM) significantly increased the frequency of spike-dependent spontaneous m1PSCs, whereas spike-independent mlPSCs remained unchanged.
    1 context sentence
    Summary · context
    Effects of two newly synthesized nootropic and anxiolytic dipeptides: Noopept and Selank on inhibitory synaptic transmission in hippocampal CA1 pyramidal cells were investigated using patch-clamp technique in whole-cell configuration.
  5. 05LabEx vivo tissueMechanism

    In stratum radiatum interneurons, current-clamp recordings supported inhibitory interneuron activation by Noopept.

    In plain wordsIn lab tests, recordings supported activation of inhibitory interneurons by Noopept.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseActivation of inhibitory interneurons
    Study

    n: not reported in source

    Hippocampal CA1 pyramidal cells and stratum radiatum inhibitory interneurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 microM · bath applicationAs given in this study.

    Source sentences

    Summary
    Results of current clamp recording of inhibitory interneurons residing in stratum radiatum confirmed this suggestion, at least for Noonent.
    2 context sentences
    Summary · context
    It was suggested that both peptides mediated their effect sue to activation of inhibitory interneurons terminating on CA1 pyramidal cells.
    Summary · context
    Effects of two newly synthesized nootropic and anxiolytic dipeptides: Noopept and Selank on inhibitory synaptic transmission in hippocampal CA1 pyramidal cells were investigated using patch-clamp technique in whole-cell configuration.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 12Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 9 times, first on 21 Oct 2026, 15:59 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    21 Oct 2026, 12:50 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    12 Oct 2026, 17:28 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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