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Study · Measured the body's own peptide · 2012

5 results

Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis.

Döring Y, Manthey HD, Drechsler M, Lievens D, Megens RT, Soehnlein O, Busch M, Manca M, Koenen RR, Pelisek J, Daemen MJ, Lutgens E and 4 more

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Zenke M, Binder CJ, Weber C, Zernecke A

Circulation2 Mar 2012Cited by 381 (Europe PMC)

PMID22388324 (opens in a new tab)DOI10.1161/circulationaha.111.046755 (opens in a new tab)PepBankPUB-22388324
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In apolipoprotein E-deficient mice, Cramp deficiency in bone marrow reduced atherosclerosis.

    In plain wordsIn mice, lacking the body's own Cramp in bone marrow cells reduced artery plaque formation.

    Peptide
    LL-37
    Outcome
    DecreaseAtherosclerosis in Cramp-deficient bone marrow
    Study

    mousen: not reported in source

    Apolipoprotein E-deficient mice
    Outcome group
    Cardiovascular events · Cardiovascular

    Source sentences

    Summary
    pDC depletion and Cramp-deficiency in bone marrow reduced atherosclerosis and anti-double-stranded DNA antibody titers.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In apolipoprotein E-deficient mice, Cramp deficiency in bone marrow reduced anti-double-stranded DNA antibody titers.

    In plain wordsIn mice, lacking the body's own Cramp in bone marrow cells lowered anti-DNA antibody levels.

    Peptide
    LL-37
    Outcome
    DecreaseAnti-dsDNA antibody titers in Cramp-deficient bone marrow
    Study

    mousen: not reported in source

    Apolipoprotein E-deficient mice
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    pDC depletion and Cramp-deficiency in bone marrow reduced atherosclerosis and anti-double-stranded DNA antibody titers.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    Cramp expression was increased in atherosclerotic arteries.

    In plain wordsThe body's own Cramp was found at higher levels in diseased arteries.

    Peptide
    LL-37
    Outcome
    IncreaseCramp expression in atherosclerotic arteries
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Cardiovascular

    Source sentences

    Summary
    we further identified increased expression of Cramp and formation of neutrophil extracellular traps in atherosclerotic arteries.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone2

In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking LL-37.

  1. 04AnimalNot a test of LL-37 aloneAnimal study (in vivo)Mechanism

    In apolipoprotein E-deficient mice, Cramp/DNA complexes aggravated atherosclerotic lesion formation.

    In plain wordsIn mice, complexes of Cramp and DNA made artery plaque formation worse.

    Peptide
    LL-37
    Outcome
    IncreaseAtherosclerotic lesion formation with Cramp/DNA complexes
    Study

    mousen: not reported in source

    Apolipoprotein E-deficient mice
    Outcome group
    Cardiovascular events · Cardiovascular

    Source sentences

    Summary
    Whereas Cramp/DNA complexes aggravated atherosclerotic lesion formation in apolipoprotein E-deficient mice

    In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.

  2. 05LabNot a test of LL-37 aloneIn vitro (cells)Mechanism

    Cramp/DNA complexes stimulated plasmacytoid dendritic cells to produce interferon-α.

    In plain wordsIn cells, complexes of Cramp and DNA made plasmacytoid dendritic cells produce interferon-α.

    Peptide
    LL-37
    Outcome
    IncreaseInterferon-α production by pDCs with Cramp/DNA complexes
    Study

    n: not reported in source

    Plasmacytoid dendritic cells
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Plasmacytoid DCs can be stimulated to produce interferon-α by Cramp/DNA complexes

    In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:57 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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