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Study · In vitro (cells) · 2012

7 results

New proangiogenic activity on vascular endothelial cells for C-terminal mechano growth factor.

Deng M, Wang Y, Zhang B, Liu P, Xiao H, Zhao J

Acta biochimica et biophysica Sinica1 Mar 2012Cited by 10 (Europe PMC)

PMID22382131 (opens in a new tab)DOI10.1093/abbs/gms012 (opens in a new tab)PepBankPUB-22382131
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human EA.hy926 endothelial cells, MGF24E at 10 ng/ml promoted the biological processes of angiogenesis compared with vehicle control.

    In plain wordsIn cells, MGF24E promoted blood vessel formation processes more than the vehicle alone.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseAngiogenesis processes (proliferation, migration, tubulogenesis)
    Study

    humann: not reported in source

    EA.hy926 human vascular endothelial cells
    Comparator
    Vehicle control (PBS)
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    10 ng/mlAs given in this study (human).

    Source sentences

    Summary
    MGF24E treatment (10 ng/ml) significantly promoted the biological processes of angiogenesis on EA.hy926 cells compared with the vehicle control.
    1 context sentence
    Summary · context
    The cell proliferation, migration, and tubulogenesis of the human vascular endothelial EA.hy926 cells co-treated with 2% serum and MGF24E were determined to assess angiogenesis in comparison with 100 ng/ml of vascular endothelial growth factor 165 (VEGF(165))-positive control or vehicle control (pho…
  2. 02LabIn vitro (cells)Activity measurement

    In EA.hy926 cells, adding 10 ng/ml of MGF24E reversed the suppression of vascular endothelial growth factor expression caused by 2% serum starvation.

    In plain wordsIn cells, MGF24E reversed the drop in VEGF caused by low serum.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseVascular endothelial growth factor expression
    Study

    humann: not reported in source

    EA.hy926 human vascular endothelial cells
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    10 ng/mlAs given in this study (human).

    Source sentences

    Summary
    The suppression of vascular endothelial growth factor and angiopoietin-I expressions by 2% serum starvation was reversed by the addition of 10 ng/ml of MGF24E in 2% serum medium.
    1 context sentence
    Summary · context
    The cell proliferation, migration, and tubulogenesis of the human vascular endothelial EA.hy926 cells co-treated with 2% serum and MGF24E were determined to assess angiogenesis in comparison with 100 ng/ml of vascular endothelial growth factor 165 (VEGF(165))-positive control or vehicle control (pho…
  3. 03LabIn vitro (cells)Activity measurement

    In EA.hy926 cells, adding 10 ng/ml of MGF24E reversed the suppression of angiopoietin-I expression caused by 2% serum starvation.

    In plain wordsIn cells, MGF24E reversed the drop in angiopoietin-I caused by low serum.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseAngiopoietin-I expression
    Study

    humann: not reported in source

    EA.hy926 human vascular endothelial cells
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    10 ng/mlAs given in this study (human).

    Source sentences

    Summary
    The suppression of vascular endothelial growth factor and angiopoietin-I expressions by 2% serum starvation was reversed by the addition of 10 ng/ml of MGF24E in 2% serum medium.
    1 context sentence
    Summary · context
    The cell proliferation, migration, and tubulogenesis of the human vascular endothelial EA.hy926 cells co-treated with 2% serum and MGF24E were determined to assess angiogenesis in comparison with 100 ng/ml of vascular endothelial growth factor 165 (VEGF(165))-positive control or vehicle control (pho…

Studies that did not test the peptide alone4

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

  1. 04LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Activity measurement

    In EA.hy926 cells, ERK inhibition by PD98050 pretreatment completely abolished MGF24E-induced proliferation.

    In plain wordsIn cells, an ERK blocker completely stopped the cell growth caused by MGF24E.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMGF24E-induced proliferation with PD98050
    Study

    humann: not reported in source

    EA.hy926 human vascular endothelial cells
    Outcome group
    Angiogenesis · Cardiovascular

    Source sentences

    Summary
    the inhibition of ERK due to PD98050 pretreatment completely abolished and mostly blocked MGF24E-induced proliferation
    1 context sentence
    Summary · context
    The cell proliferation, migration, and tubulogenesis of the human vascular endothelial EA.hy926 cells co-treated with 2% serum and MGF24E were determined to assess angiogenesis in comparison with 100 ng/ml of vascular endothelial growth factor 165 (VEGF(165))-positive control or vehicle control (pho…

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  2. 05LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Activity measurement

    In EA.hy926 cells, ERK inhibition by PD98050 pretreatment mostly blocked MGF24E-induced migration.

    In plain wordsIn cells, an ERK blocker mostly stopped the cell movement caused by MGF24E.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMGF24E-induced migration with PD98050
    Study

    humann: not reported in source

    EA.hy926 human vascular endothelial cells
    Outcome group
    Angiogenesis · Cardiovascular

    Source sentences

    Summary
    Moreover, the inhibition of ERK due to PD98050 pretreatment completely abolished and mostly blocked MGF24E-induced proliferation and migration, respectively, whereas the MGF24-induced tubulogenesis and the angiogenic factor expression were only partially inhibited.
    1 context sentence
    Summary · context
    The cell proliferation, migration, and tubulogenesis of the human vascular endothelial EA.hy926 cells co-treated with 2% serum and MGF24E were determined to assess angiogenesis in comparison with 100 ng/ml of vascular endothelial growth factor 165 (VEGF(165))-positive control or vehicle control (pho…

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  3. 06LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Activity measurement

    In EA.hy926 cells, ERK inhibition by PD98050 only partially inhibited MGF24-induced tubulogenesis.

    In plain wordsIn cells, an ERK blocker only partly stopped the tube formation caused by MGF24E.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMGF24E-induced tubulogenesis with PD98050
    Study

    humann: not reported in source

    EA.hy926 human vascular endothelial cells
    Outcome group
    Angiogenesis · Cardiovascular

    Source sentences

    Summary
    Moreover, the inhibition of ERK due to PD98050 pretreatment completely abolished and mostly blocked MGF24E-induced proliferation and migration, respectively, whereas the MGF24-induced tubulogenesis and the angiogenic factor expression were only partially inhibited.
    1 context sentence
    Summary · context
    The cell proliferation, migration, and tubulogenesis of the human vascular endothelial EA.hy926 cells co-treated with 2% serum and MGF24E were determined to assess angiogenesis in comparison with 100 ng/ml of vascular endothelial growth factor 165 (VEGF(165))-positive control or vehicle control (pho…

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  4. 07LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Activity measurement

    In EA.hy926 cells, ERK inhibition by PD98050 only partially inhibited MGF24-induced angiogenic factor expression.

    In plain wordsIn cells, an ERK blocker only partly stopped the rise in blood vessel growth factors caused by MGF24E.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMGF24E-induced angiogenic factor expression with PD98050
    Study

    humann: not reported in source

    EA.hy926 human vascular endothelial cells
    Outcome group
    Angiogenesis · Cardiovascular

    Source sentences

    Summary
    Moreover, the inhibition of ERK due to PD98050 pretreatment completely abolished and mostly blocked MGF24E-induced proliferation and migration, respectively, whereas the MGF24-induced tubulogenesis and the angiogenic factor expression were only partially inhibited.
    1 context sentence
    Summary · context
    The cell proliferation, migration, and tubulogenesis of the human vascular endothelial EA.hy926 cells co-treated with 2% serum and MGF24E were determined to assess angiogenesis in comparison with 100 ng/ml of vascular endothelial growth factor 165 (VEGF(165))-positive control or vehicle control (pho…

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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