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Study · Not a test of the peptide alone · 2012

4 results

Comparison of low and high dose cosyntropin stimulation tests in the diagnosis of adrenal insufficiency in septic shock patients.

Moraes RB, Friedman G, Tonietto T, Saltz H, Czepielewski M

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme20 Feb 2012Cited by 8 (Europe PMC)

PMID22351474 (opens in a new tab)DOI10.1055/s-0032-1304320 (opens in a new tab)PepBankPUB-22351474
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cosyntropin.

  1. 01HumanNot a test of Cosyntropin aloneObservational studyOther

    In septic shock patients, low-dose and high-dose cosyntropin responses correlated moderately (r(s)=0.55).

    In plain wordsIn septic shock patients, responses to low-dose and high-dose cosyntropin tests correlated moderately.

    Peptide
    Cosyntropin
    Outcome
    Not applicableLow-dose versus high-dose response correlation
    Study

    n = 74

    Comparator
    High-dose cosyntropin test
    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Measurements

    Correlation r(s) between low-dose and high-dose cosyntropin response
    0.55
    septic shock patients

    Source sentences

    Summary
    There was a moderate correlation in response to low and high dose cosyntropin, r(s)=0.55.
    1 context sentence
    Summary · context
    Prospective noninterventional study included 74 septic shock patients. After measurement of baseline cortisol all patients received 1 μg of cosyntropin i. v. and 4 h later 249 μg of cosyntropin.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  2. 02HumanNot a test of Cosyntropin aloneObservational studyOther

    In septic shock patients, low-dose and high-dose cosyntropin responses were equally accurate for identifying mortality.

    In plain wordsIn septic shock patients, low-dose and high-dose cosyntropin responses had equal accuracy for identifying mortality.

    Peptide
    Cosyntropin
    Outcome
    No significant changeMortality identification accuracy
    Study

    n = 74

    Comparator
    High-dose cosyntropin test
    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Source sentences

    Summary
    The increase induced by both tests was equally accurate to identify mortality and time of vasopressor withdrawal.
    1 context sentence
    Summary · context
    Prospective noninterventional study included 74 septic shock patients. After measurement of baseline cortisol all patients received 1 μg of cosyntropin i. v. and 4 h later 249 μg of cosyntropin.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  3. 03HumanNot a test of Cosyntropin aloneObservational studyOther

    In septic shock patients, low-dose and high-dose cosyntropin responses were equally accurate for identifying time of vasopressor withdrawal.

    In plain wordsIn septic shock patients, low-dose and high-dose cosyntropin responses had equal accuracy for identifying vasopressor withdrawal time.

    Peptide
    Cosyntropin
    Outcome
    No significant changeVasopressor withdrawal time identification accuracy
    Study

    n = 74

    Comparator
    High-dose cosyntropin test
    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Source sentences

    Summary
    The increase induced by both tests was equally accurate to identify mortality and time of vasopressor withdrawal.
    1 context sentence
    Summary · context
    Prospective noninterventional study included 74 septic shock patients. After measurement of baseline cortisol all patients received 1 μg of cosyntropin i. v. and 4 h later 249 μg of cosyntropin.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  4. 04HumanNot a test of Cosyntropin aloneObservational studyOther

    In septic shock patients with baseline cortisol between 10-34 μg/dl, low-dose and high-dose responses correlated (r(s)=0.67).

    In plain wordsIn septic shock patients with intermediary baseline cortisol, low-dose and high-dose cosyntropin responses correlated.

    Peptide
    Cosyntropin
    Outcome
    Not applicableResponse correlation with intermediary baseline cortisol
    Study

    n: not reported in source

    Comparator
    High-dose cosyntropin test
    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Measurements

    Correlation r(s) between low-dose and high-dose cosyntropin response
    0.67
    baseline cortisol 10-34 ug/dl

    Source sentences

    Summary
    This correlation in patients with baseline cortisol between 10-34 μg/dl is, r(s)=0.67.
    1 context sentence
    Summary · context
    Prospective noninterventional study included 74 septic shock patients. After measurement of baseline cortisol all patients received 1 μg of cosyntropin i. v. and 4 h later 249 μg of cosyntropin.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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