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Study · Animal study (in vivo) · goldfish · 2012

4 results

GHRP-6 mimics ghrelin-induced stimulation of food intake and suppression of locomotor activity in goldfish.

Yahashi S, Kang KS, Kaiya H, Matsuda K

Peptides13 Feb 2012Cited by 15 (Europe PMC)

PMID22349352 (opens in a new tab)DOI10.1016/j.peptides.2012.01.025 (opens in a new tab)PepBankPUB-22349352
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In goldfish, GHRP‑6 stimulated food intake.

    In plain wordsIn goldfish, GHRP‑6 increased food intake.

    Peptide
    GHRP-6
    Outcome
    IncreaseFood intake
    Study

    goldfishn: not reported in source

    goldfish
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    1 pmol/g body weight · intraperitonealAs given in this study (goldfish).

    Source sentences

    Summary
    IP administration of GHRP-6 at 1pmol/g body weight (BW) stimulated food intake, and was equipotent to the orexigenic action of n-octanoyl ghrelin17 at 10 pmol/g BW.
    1 context sentence
    Summary · context
    Therefore, in the present study, we examined whether IP-administered GHRP-6 would mimic the orexigenic action of n-octanoyl ghrelin17 and its suppression of locomotor activity.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In goldfish, GHRP‑6 at 1 pmol/g BW was equipotent to n-octanoyl ghrelin17 at 10 pmol/g BW for stimulating food intake.

    In plain wordsIn goldfish, GHRP‑6 stimulated food intake as strongly as n-octanoyl ghrelin17 at the reported doses.

    Peptide
    GHRP-6
    Outcome
    No significant changeOrexigenic potency
    Study

    goldfishn: not reported in source

    goldfish
    Comparator
    n-octanoyl ghrelin17 at 10 pmol/g BW
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    1 pmol/g body weight · intraperitonealAs given in this study (goldfish).

    Source sentences

    Summary
    IP administration of GHRP-6 at 1pmol/g body weight (BW) stimulated food intake, and was equipotent to the orexigenic action of n-octanoyl ghrelin17 at 10 pmol/g BW.
    1 context sentence
    Summary · context
    Therefore, in the present study, we examined whether IP-administered GHRP-6 would mimic the orexigenic action of n-octanoyl ghrelin17 and its suppression of locomotor activity.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In goldfish, injected GHRP‑6 significantly decreased locomotor activity.

    In plain wordsIn goldfish, injected GHRP‑6 reduced movement.

    Peptide
    GHRP-6
    Outcome
    DecreaseLocomotor activity
    Study

    goldfishn: not reported in source

    goldfish
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    1 pmol/g body weight · intraperitonealAs given in this study (goldfish).

    Source sentences

    Summary
    IP-injected GHRP-6 at 1 pmol/g BW also induced a significant decrease of locomotor activity, as was the case for IP-injected n-octanoyl ghrelin17 at 10 pmol/g BW.
    1 context sentence
    Summary · context
    Therefore, in the present study, we examined whether IP-administered GHRP-6 would mimic the orexigenic action of n-octanoyl ghrelin17 and its suppression of locomotor activity.

Studies that did not test the peptide alone1

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 04AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In goldfish, capsaicin pretreatment blocked the action of GHRP‑6.

    In plain wordsIn goldfish, capsaicin pretreatment blocked GHRP‑6's action.

    Peptide
    GHRP-6
    Outcome
    DecreaseCapsaicin blockade of GHRP-6 action
    Study

    goldfishn: not reported in source

    goldfish
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    The action of GHRP-6 was blocked by IP-preinjected capsaicin at 160 nmol/g BW.
    1 context sentence
    Summary · context
    Therefore, in the present study, we examined whether IP-administered GHRP-6 would mimic the orexigenic action of n-octanoyl ghrelin17 and its suppression of locomotor activity.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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