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Study · Not a test of the peptide alone · 2012

1 result

Intracerebroventricular administration of metformin inhibits ghrelin-induced Hypothalamic AMP-kinase signalling and food intake.

Stevanovic D, Janjetovic K, Misirkic M, Vucicevic L, Sumarac-Dumanovic M, Micic D, Starcevic V, Trajkovic V

Neuroendocrinology14 Feb 2012Cited by 37 (Europe PMC)

PMID22343549 (opens in a new tab)DOI10.1159/000333963 (opens in a new tab)PepBankPUB-22343549
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In rats, metformin reduced AICAR-induced food consumption compared with AICAR challenge alone.

    In plain wordsIn rats, metformin reduced AICAR-induced food consumption compared with AICAR challenge alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseAICAR-induced food consumption
    Study

    ratn: not reported in source

    intracerebroventricular AICAR challenge
    Comparator
    AICAR-induced food consumption without metformin
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    Metformin also reduced food consumption induced by the AMPK activator AICAR
    2 context sentences
    Summary · context
    Rats were injected intracerebroventricularly with ghrelin (5 µg), metformin (50, 100 or 200 µg), 5-amino-imidazole-4-carboxamide 1-β-D-ribofuranoside (AICAR, 25 µg) and L-leucine (1 µg) in different combinations.
    Summary · context
    Food intake was monitored during the next 4 h.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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