AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney.

Lempiäinen J, Finckenberg P, Levijoki J, Mervaala E

British journal of pharmacology1 Jul 2012Cited by 117 (Europe PMC)

PMID22324445PMCIDPMC3402813DOI10.1111/j.1476-5381.2012.01895.xPepBankPUB-22324445

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with kidney I/R, the highest AICAR dose decreased serum creatinine compared with I/R alone.
In plain wordsIn rats with kidney I/R, the highest AICAR dose decreased serum creatinine compared with I/R alone.
Peptide
AICAR (acadesine)
Outcome
DecreaseSerum creatinine
Study
ratn: not reported in source
Sprague Dawley renal ischemia/reperfusion
Comparator
I/R group
Outcome group
Kidney function · Kidney and urinary
Studied dose
500 mg·kg(-1) · intravenousAs given in this study (rat).
Source sentences
Summary
KEY RESULTS Highest dose of AICAR decreased serum creatinine and urea levels, attenuated I/R injury-induced nitrosative stress and monocyte/macrophage infiltration, and ameliorated the development of ATN.
2 context sentences(design, population, supporting numbers)
Summary · context
EXPERIMENTAL APPROACH Eight-week-old Sprague Dawley rats were divided into five groups: (i) sham-operated group; (ii) I/R group (40 min bilateral ischaemia followed by 24 h of reperfusion; (iii) I/R group + AICAR 50 mg·kg(-1) i.v. given 60 min before operation; (iv).
Summary · context
I/R group + AICAR 160 mg·kg(-1) i.v; (v) I/R group + AICAR 500 mg·kg(-1) i.v.
Report a problemFND-2232444501
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with kidney I/R, the highest AICAR dose decreased serum urea compared with I/R alone.
In plain wordsIn rats with kidney I/R, the highest AICAR dose decreased serum urea compared with I/R alone.
Peptide
AICAR (acadesine)
Outcome
DecreaseSerum urea
Study
ratn: not reported in source
Sprague Dawley renal ischemia/reperfusion
Comparator
I/R group
Outcome group
Kidney function · Kidney and urinary
Studied dose
500 mg·kg(-1) · intravenousAs given in this study (rat).
Source sentences
Summary
KEY RESULTS Highest dose of AICAR decreased serum creatinine and urea levels, attenuated I/R injury-induced nitrosative stress and monocyte/macrophage infiltration, and ameliorated the development of ATN.
2 context sentences(design, population, supporting numbers)
Summary · context
EXPERIMENTAL APPROACH Eight-week-old Sprague Dawley rats were divided into five groups: (i) sham-operated group; (ii) I/R group (40 min bilateral ischaemia followed by 24 h of reperfusion; (iii) I/R group + AICAR 50 mg·kg(-1) i.v. given 60 min before operation; (iv).
Summary · context
I/R group + AICAR 160 mg·kg(-1) i.v; (v) I/R group + AICAR 500 mg·kg(-1) i.v.
Report a problemFND-2232444502
03AnimalAnimal study (in vivo)Mechanism
In rats with kidney I/R, the highest AICAR dose attenuated nitrosative stress compared with I/R alone.
In plain wordsIn rats with kidney I/R, the highest AICAR dose reduced nitrosative stress compared with I/R alone.
Peptide
AICAR (acadesine)
Outcome
DecreaseNitrosative stress
Study
ratn: not reported in source
Sprague Dawley renal ischemia/reperfusion
Comparator
I/R group
Outcome group
Oxidative stress · Kidney and urinary
Studied dose
500 mg·kg(-1) · intravenousAs given in this study (rat).
Source sentences
Summary
KEY RESULTS Highest dose of AICAR decreased serum creatinine and urea levels, attenuated I/R injury-induced nitrosative stress and monocyte/macrophage infiltration, and ameliorated the development of ATN.
2 context sentences(design, population, supporting numbers)
Summary · context
EXPERIMENTAL APPROACH Eight-week-old Sprague Dawley rats were divided into five groups: (i) sham-operated group; (ii) I/R group (40 min bilateral ischaemia followed by 24 h of reperfusion; (iii) I/R group + AICAR 50 mg·kg(-1) i.v. given 60 min before operation; (iv).
Summary · context
I/R group + AICAR 160 mg·kg(-1) i.v; (v) I/R group + AICAR 500 mg·kg(-1) i.v.
Report a problemFND-2232444503
04AnimalAnimal study (in vivo)Mechanism
In rats with kidney I/R, the highest AICAR dose attenuated monocyte/macrophage infiltration compared with I/R alone.
In plain wordsIn rats with kidney I/R, the highest AICAR dose reduced immune-cell infiltration compared with I/R alone.
Peptide
AICAR (acadesine)
Outcome
DecreaseMonocyte/macrophage infiltration
Study
ratn: not reported in source
Sprague Dawley renal ischemia/reperfusion
Comparator
I/R group
Outcome group
Inflammation markers · Kidney and urinary
Studied dose
500 mg·kg(-1) · intravenousAs given in this study (rat).
Source sentences
Summary
KEY RESULTS Highest dose of AICAR decreased serum creatinine and urea levels, attenuated I/R injury-induced nitrosative stress and monocyte/macrophage infiltration, and ameliorated the development of ATN.
2 context sentences(design, population, supporting numbers)
Summary · context
EXPERIMENTAL APPROACH Eight-week-old Sprague Dawley rats were divided into five groups: (i) sham-operated group; (ii) I/R group (40 min bilateral ischaemia followed by 24 h of reperfusion; (iii) I/R group + AICAR 50 mg·kg(-1) i.v. given 60 min before operation; (iv).
Summary · context
I/R group + AICAR 160 mg·kg(-1) i.v; (v) I/R group + AICAR 500 mg·kg(-1) i.v.
Report a problemFND-2232444504
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with kidney I/R, the highest AICAR dose ameliorated acute tubular necrosis compared with I/R alone.
In plain wordsIn rats with kidney I/R, the highest AICAR dose reduced acute tubular necrosis compared with I/R alone.
Peptide
AICAR (acadesine)
Outcome
DecreaseAcute tubular necrosis
Study
ratn: not reported in source
Sprague Dawley renal ischemia/reperfusion
Comparator
I/R group
Outcome group
Kidney function · Kidney and urinary
Studied dose
500 mg·kg(-1) · intravenousAs given in this study (rat).
Source sentences
Summary
KEY RESULTS Highest dose of AICAR decreased serum creatinine and urea levels, attenuated I/R injury-induced nitrosative stress and monocyte/macrophage infiltration, and ameliorated the development of ATN.
2 context sentences(design, population, supporting numbers)
Summary · context
EXPERIMENTAL APPROACH Eight-week-old Sprague Dawley rats were divided into five groups: (i) sham-operated group; (ii) I/R group (40 min bilateral ischaemia followed by 24 h of reperfusion; (iii) I/R group + AICAR 50 mg·kg(-1) i.v. given 60 min before operation; (iv).
Summary · context
I/R group + AICAR 160 mg·kg(-1) i.v; (v) I/R group + AICAR 500 mg·kg(-1) i.v.
Report a problemFND-2232444505
06AnimalAnimal study (in vivo)Mechanism
In rats with kidney I/R, AICAR increased the pAMPK/AMPK ratio compared with I/R alone.
In plain wordsIn rats with kidney I/R, AICAR increased the pAMPK/AMPK ratio compared with I/R alone.
Peptide
AICAR (acadesine)
Outcome
IncreasepAMPK/AMPK ratio
Study
ratn: not reported in source
Sprague Dawley renal ischemia/reperfusion
Comparator
I/R group
Outcome group
Receptor activity and mechanism · Kidney and urinary
Studied dose
Dose not stated · intravenousAs given in this study (rat).
Source sentences
Summary
AICAR increased pAMPK/AMPK ratio and prevented the I/R-induced increase in renal SIRT1 expression.
2 context sentences(design, population, supporting numbers)
Summary · context
EXPERIMENTAL APPROACH Eight-week-old Sprague Dawley rats were divided into five groups: (i) sham-operated group; (ii) I/R group (40 min bilateral ischaemia followed by 24 h of reperfusion; (iii) I/R group + AICAR 50 mg·kg(-1) i.v. given 60 min before operation; (iv).
Summary · context
I/R group + AICAR 160 mg·kg(-1) i.v; (v) I/R group + AICAR 500 mg·kg(-1) i.v.
Report a problemFND-2232444506
07AnimalAnimal study (in vivo)Mechanism
In rats with kidney I/R, AICAR prevented the injury-induced increase in renal SIRT1 expression compared with I/R alone.
In plain wordsIn rats with kidney I/R, AICAR prevented the increase in renal SIRT1 expression compared with I/R alone.
Peptide
AICAR (acadesine)
Outcome
DecreaseRenal SIRT1 expression
Study
ratn: not reported in source
Sprague Dawley renal ischemia/reperfusion
Comparator
I/R group
Outcome group
Receptor activity and mechanism · Kidney and urinary
Studied dose
Dose not stated · intravenousAs given in this study (rat).
Source sentences
Summary
AICAR increased pAMPK/AMPK ratio and prevented the I/R-induced increase in renal SIRT1 expression.
2 context sentences(design, population, supporting numbers)
Summary · context
EXPERIMENTAL APPROACH Eight-week-old Sprague Dawley rats were divided into five groups: (i) sham-operated group; (ii) I/R group (40 min bilateral ischaemia followed by 24 h of reperfusion; (iii) I/R group + AICAR 50 mg·kg(-1) i.v. given 60 min before operation; (iv).
Summary · context
I/R group + AICAR 160 mg·kg(-1) i.v; (v) I/R group + AICAR 500 mg·kg(-1) i.v.
Report a problemFND-2232444507

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

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